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| Home > Publications database > The replicability crisis and the multivariate perspective in mapping brain structure to behavioral phenotype |
| Home > Publications database > The replicability crisis and the multivariate perspective in mapping brain structure to behavioral phenotype |
| Conference Presentation (Invited) | FZJ-2024-05531 |
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2024
Abstract: “What are the brain structural correlates of interindividual differences in behaviour?” More than a decade ago, advances in structural MRI opened promising perspectives to address this question. In our work, we haveinvestigated the replicability of associations between local measurements of neuroanatomy and isolated behavioural variables, including personality measures. Across subsampling within large opendatasets (such the NKI and HCP datasets), we generally found very low replicability rates. Given these replicability issues that were also highlighted in other studies and broadening scepticisms regarding theidea of one-to-one mappings between psychological constructs and brain regions, new perspectives embracing the multivariate nature of structural brain-behaviour relationships emerged. In our more recentwork, we illustrated how multivariate approaches in large datasets (such as the HCP datasets) can reveal complex, but robust, patterns of brain-behaviour relationships spanning across behavioral domains (fromcognitive measures to personality-related measures) in the population data.
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