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@INPROCEEDINGS{Ito:1031973,
author = {Ito, Junji and Essink, Simon and Riehle, Alexa and
Brochier, Thomas and Grün, Sonja},
title = {{S}ensory and behavioural tuning along the dorsal pathway},
reportid = {FZJ-2024-05897},
year = {2024},
abstract = {Directional tuning of motor cortex neurons is typically
characterized by a sinusoidal tuning curve with a preferred
direction (PD) represented by its peak. While PDs across
neurons were assumed to be uniformly distributed over all
directions, recent experiments reported a bimodal
distribution of hand movement PDs when the movements are
constrained to a horizontal work area. Several modelling
studies attribute this to the limb biomechanics, which
indicates more kinetic (muscle force based) rather than
kinematic (movement parameter based) representation in the
motor cortex. We conducted neuronal recordings in behaving
macaques to elucidate to what extent this kinetic tuning
extends down along the dorsal pathway. The monkeys were
trained for a visually guided reaching task in the
horizontal plane. Spiking activity was recorded in visual
(V1/V2), parietal (DP, 7A) and motor (M1/PMd) areas. To
estimate the tuning curve of each neuron to sensory and
behavioural modalities, we regressed the spiking activity of
each neuron on all available behavioural and sensory
covariates (visual input, eye/hand position, saccade, hand
movement direction and speed) at once by using generalized
linear models. The model fitting results reveal a gradual
shift in visual and motor tuning along the dorsal pathway:
increasing of motor and decreasing of visual tuning towards
the motor cortex. We confirm the bimodal hand movement PD
distribution in M1/PMd, and also find, after eliminating the
confounding effect of the visual tuning, similar bimodal PD
distributions in V1/V2, DP and 7A, suggesting an influence
of limb biomechanics even in the lower hierarchy levels of
the dorsal visual stream.},
month = {Sep},
date = {2024-09-26},
organization = {Seeing and Acting Workshop: Functional
and Neural Perspectives, Coimbra
(Portugal), 26 Sep 2024 - 28 Sep 2024},
subtyp = {After Call},
cin = {IAS-6 / INM-10},
cid = {I:(DE-Juel1)IAS-6-20130828 / I:(DE-Juel1)INM-10-20170113},
pnm = {5231 - Neuroscientific Foundations (POF4-523) / HBP SGA2 -
Human Brain Project Specific Grant Agreement 2 (785907) /
HBP SGA3 - Human Brain Project Specific Grant Agreement 3
(945539) / HAF - Helmholtz Analytics Framework (ZT-I-0003) /
JL SMHB - Joint Lab Supercomputing and Modeling for the
Human Brain (JL SMHB-2021-2027) / Algorithms of Adaptive
Behavior and their Neuronal Implementation in Health and
Disease (iBehave-20220812) / GRK 2416 - GRK 2416:
MultiSenses-MultiScales: Neue Ansätze zur Aufklärung
neuronaler multisensorischer Integration (368482240)},
pid = {G:(DE-HGF)POF4-5231 / G:(EU-Grant)785907 /
G:(EU-Grant)945539 / G:(DE-HGF)ZT-I-0003 / G:(DE-Juel1)JL
SMHB-2021-2027 / G:(DE-Juel-1)iBehave-20220812 /
G:(GEPRIS)368482240},
typ = {PUB:(DE-HGF)6},
url = {https://juser.fz-juelich.de/record/1031973},
}