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@INPROCEEDINGS{Ito:1031973,
      author       = {Ito, Junji and Essink, Simon and Riehle, Alexa and
                      Brochier, Thomas and Grün, Sonja},
      title        = {{S}ensory and behavioural tuning along the dorsal pathway},
      reportid     = {FZJ-2024-05897},
      year         = {2024},
      abstract     = {Directional tuning of motor cortex neurons is typically
                      characterized by a sinusoidal tuning curve with a preferred
                      direction (PD) represented by its peak. While PDs across
                      neurons were assumed to be uniformly distributed over all
                      directions, recent experiments reported a bimodal
                      distribution of hand movement PDs when the movements are
                      constrained to a horizontal work area. Several modelling
                      studies attribute this to the limb biomechanics, which
                      indicates more kinetic (muscle force based) rather than
                      kinematic (movement parameter based) representation in the
                      motor cortex. We conducted neuronal recordings in behaving
                      macaques to elucidate to what extent this kinetic tuning
                      extends down along the dorsal pathway. The monkeys were
                      trained for a visually guided reaching task in the
                      horizontal plane. Spiking activity was recorded in visual
                      (V1/V2), parietal (DP, 7A) and motor (M1/PMd) areas. To
                      estimate the tuning curve of each neuron to sensory and
                      behavioural modalities, we regressed the spiking activity of
                      each neuron on all available behavioural and sensory
                      covariates (visual input, eye/hand position, saccade, hand
                      movement direction and speed) at once by using generalized
                      linear models. The model fitting results reveal a gradual
                      shift in visual and motor tuning along the dorsal pathway:
                      increasing of motor and decreasing of visual tuning towards
                      the motor cortex. We confirm the bimodal hand movement PD
                      distribution in M1/PMd, and also find, after eliminating the
                      confounding effect of the visual tuning, similar bimodal PD
                      distributions in V1/V2, DP and 7A, suggesting an influence
                      of limb biomechanics even in the lower hierarchy levels of
                      the dorsal visual stream.},
      month         = {Sep},
      date          = {2024-09-26},
      organization  = {Seeing and Acting Workshop: Functional
                       and Neural Perspectives, Coimbra
                       (Portugal), 26 Sep 2024 - 28 Sep 2024},
      subtyp        = {After Call},
      cin          = {IAS-6 / INM-10},
      cid          = {I:(DE-Juel1)IAS-6-20130828 / I:(DE-Juel1)INM-10-20170113},
      pnm          = {5231 - Neuroscientific Foundations (POF4-523) / HBP SGA2 -
                      Human Brain Project Specific Grant Agreement 2 (785907) /
                      HBP SGA3 - Human Brain Project Specific Grant Agreement 3
                      (945539) / HAF - Helmholtz Analytics Framework (ZT-I-0003) /
                      JL SMHB - Joint Lab Supercomputing and Modeling for the
                      Human Brain (JL SMHB-2021-2027) / Algorithms of Adaptive
                      Behavior and their Neuronal Implementation in Health and
                      Disease (iBehave-20220812) / GRK 2416 - GRK 2416:
                      MultiSenses-MultiScales: Neue Ansätze zur Aufklärung
                      neuronaler multisensorischer Integration (368482240)},
      pid          = {G:(DE-HGF)POF4-5231 / G:(EU-Grant)785907 /
                      G:(EU-Grant)945539 / G:(DE-HGF)ZT-I-0003 / G:(DE-Juel1)JL
                      SMHB-2021-2027 / G:(DE-Juel-1)iBehave-20220812 /
                      G:(GEPRIS)368482240},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/1031973},
}