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@ARTICLE{Bhalani:1032175,
      author       = {Bhalani, Deep and Sharma, Anish Kumar and Kuperkar, Ketan
                      and Singla, Pankaj and Ray, Debes and Aswal, Vinod K. and
                      Pillai, Sadafara A.},
      title        = {{D}enaturants and {S}olutol® {HS}15 in ophthalmic
                      formulations: {I}nsights into their combined effects},
      journal      = {Journal of molecular liquids},
      volume       = {414},
      issn         = {0167-7322},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2024-06045},
      pages        = {126289 -},
      year         = {2024},
      abstract     = {In the field of ophthalmology, significant attention is
                      dedicated to developing micellar carriers to enhance ocular
                      drug delivery. Urea is a well-known denaturant and has been
                      used as an excipient in several ocular formulations due to
                      its efficacy as an ocular hypotensive agent. The presence of
                      urea as an excipient may influence the characteristics of
                      the micellar nanocarrier in the formulation and needs to be
                      investigated. Solutol® HS15, a wellknown nonionic
                      surfactant and a commonly used
                      nanocarrierindrugformulations, enhances the solubilization
                      and stability of ocular drugs. However, a detailed study of
                      its interaction with various pharmaceutical excipients is
                      still lacking. With this intention, the present study
                      focuses on comprehending the interaction between Solutol®
                      HS15 micelles with urea and its derivatives. Here, we
                      present a detailed analysis on the influence of urea and its
                      derivatives (methylurea, dimethylurea) on Solutol® HS15
                      using small-angle neutron scattering (SANS), dynamic light
                      scattering (DLS), and cloud point (CP) measurements. The
                      presence of urea and its derivatives strongly affects the
                      CP, leading to a significant increase in its values when
                      urea derivatives are present. Additionally, the SANS and DLS
                      results also indicate a significant decrease in micellar
                      size, suggesting demicellization. The observed effects of
                      urea derivatives on Solutol® HS15 micelles underscore the
                      importance of considering solventsurfactant interactions in
                      understanding the behavior of surfactant based systems. This
                      research will provide greater insight into the interactions
                      between urea and its derivatives and Solutol® HS15, which
                      will assist in understanding the morphology and size
                      distribution of surfactant micelles for drug delivery
                      applications.},
      cin          = {IBI-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-4-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524) / DFG project G:(GEPRIS)495795796 - Das
                      Phasenverhalten von Proteinlösungen in elektrischen Feldern
                      (495795796)},
      pid          = {G:(DE-HGF)POF4-5241 / G:(GEPRIS)495795796},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.molliq.2024.126289},
      url          = {https://juser.fz-juelich.de/record/1032175},
}