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| Home > Publications database > Denaturants and Solutol® HS15 in ophthalmic formulations: Insights into their combined effects |
| Home > Publications database > Denaturants and Solutol® HS15 in ophthalmic formulations: Insights into their combined effects |
| Journal Article | FZJ-2024-06045 |
; ; ; ; ; ;
2024
Elsevier
New York, NY [u.a.]
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Please use a persistent id in citations: doi:10.1016/j.molliq.2024.126289
Abstract: In the field of ophthalmology, significant attention is dedicated to developing micellar carriers to enhance ocular drug delivery. Urea is a well-known denaturant and has been used as an excipient in several ocular formulations due to its efficacy as an ocular hypotensive agent. The presence of urea as an excipient may influence the characteristics of the micellar nanocarrier in the formulation and needs to be investigated. Solutol® HS15, a wellknown nonionic surfactant and a commonly used nanocarrierindrugformulations, enhances the solubilization and stability of ocular drugs. However, a detailed study of its interaction with various pharmaceutical excipients is still lacking. With this intention, the present study focuses on comprehending the interaction between Solutol® HS15 micelles with urea and its derivatives. Here, we present a detailed analysis on the influence of urea and its derivatives (methylurea, dimethylurea) on Solutol® HS15 using small-angle neutron scattering (SANS), dynamic light scattering (DLS), and cloud point (CP) measurements. The presence of urea and its derivatives strongly affects the CP, leading to a significant increase in its values when urea derivatives are present. Additionally, the SANS and DLS results also indicate a significant decrease in micellar size, suggesting demicellization. The observed effects of urea derivatives on Solutol® HS15 micelles underscore the importance of considering solventsurfactant interactions in understanding the behavior of surfactant based systems. This research will provide greater insight into the interactions between urea and its derivatives and Solutol® HS15, which will assist in understanding the morphology and size distribution of surfactant micelles for drug delivery applications.
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