Dataset

FZJ-2024-07273

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Muscarinic acetylcholine M2 receptor densities in areas of the rat iso- and proisocortex (v1)

Kuckertz, A.FZJ* ; Haghir, H. ; Zilles, K. ; Palomero-Gallagher, N. (Corresponding author)FZJ*

2024
EBRAINS

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Please use a persistent id in citations: doi:10.25493/XSGR-HXQ

Abstract: The present dataset provides the densities of a key neuromodulatory molecule in signal transfer, namely the muscarinic acetylcholine M 2 receptor, in all isocortical and proisocortical areas of the rat brain. The agonistic binding site of the M 2 receptors were visualized by means of quantitative *in vitro* receptor autoradiography and the selective tritiated ligand oxotremorine-M following an established experimental protocol, and neighbouring sections were processed histologically for the visualization of cell bodies. Isocortical and proisocortical areas were identified based on cytoarchitectonic criteria and differences in the regional and laminar distribution of the M 2 receptor, and receptor densities quantified by densitometric analysis. We provide here the M 2 receptor densities of 48 architectonically distinct areas belonging to the entire rat iso- and proisocortex.

Keyword(s): Neuroscience

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
3. HIBALL - Helmholtz International BigBrain Analytics and Learning Laboratory (HIBALL) (InterLabs-0015) (InterLabs-0015)
4. EBRAINS 2.0 - EBRAINS 2.0: A Research Infrastructure to Advance Neuroscience and Brain Health (101147319) (101147319)

Appears in the scientific report 2024

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