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@ARTICLE{Rttgen:1035306,
      author       = {Röttgen, Sinah and Fink, Gereon Rudolf and Sommerauer,
                      Michael and Anja, Ophey and Doppler, Christopher and Aline,
                      Seger},
      title        = {{N}on-{M}otor symptoms in prodromal{P}arkinson’s disease
                      are linked to reduced{Q}uality of {L}ife},
      journal      = {Journal of Parkinson's Disease},
      volume       = {15},
      number       = {2},
      issn         = {1877-7171},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {FZJ-2025-00364},
      pages        = {434 - 439},
      year         = {2025},
      note         = {The authors disclosed receipt of the following financial
                      support for the research, authorship, and/or publication of
                      this article: C.E.J.D. is supported by the Clinician
                      Scientist Program (CCSP), funded by the Deutsche
                      Forschungsgemeinschaft (DFG, German Research Foundation, FI
                      773/15-1). G.R.F. receives grants from Deutsche
                      Forschungsgemeinschaft (DFG, German Research Foundation),
                      Project-ID 431549029, SFB 1451. A.O. received a grant from
                      the Koeln Fortune Program (grant-no. 329/2021), Faculty of
                      Medicine, University of Cologne, and the
                      “Novartis-Stiftung für therapeutische Forschung”, both
                      outside the submitted work. M.S. received grants from the
                      Else Kröner-Fresenius-Stiftung (grant number
                      $2019_EKES.02),$ and the Koeln Fortune Program, Faculty of
                      Medicine, University of Cologne. M.S. receives additional
                      funding from the program “Netzwerke 2021”, an initiative
                      of the Ministry of Culture and Science of the State of
                      Northrhine Westphalia. The Federal Ministry of Education and
                      Research (BMBF) is funding the project within the framework
                      of the funding programme ACCENT (funding code 01EO2107).
                      Open access publication was funded by the Deutsche
                      Forschungsgemeinschaft (DFG, German Research Foundation) –
                      491111487.},
      abstract     = {Isolated rapid eye movement (REM) sleep behavior disorder
                      (iRBD) highlights an early α-synucleinopathy. This study
                      compared health-related quality of life (hrQoL) in 62
                      individuals with iRBD with 19 healthy controls (HC) and 29
                      individuals with Parkinson's disease (PD) and identified
                      factors linked to poorer hrQoL. HrQoL was significantly
                      lower in individuals with iRBD (83.33 ± 16.96) compared
                      to HC (92.29 ± 5.49, p = 0.027). Poorer hrQoL in
                      individuals with iRBD was linked to severity of multiple
                      non-motor symptoms, most prominently fatigue and depressive
                      symptoms being significant predictors (p < 0.001,
                      adjusted R2 = 0.81). This study highlights the
                      importance of non-motor symptoms for hrQoL in prodromal PD.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / DFG
                      project G:(GEPRIS)431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029) / DFG project
                      G:(GEPRIS)491111487 - Open-Access-Publikationskosten / 2025
                      - 2027 / Forschungszentrum Jülich (OAPKFZJ) (491111487)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(GEPRIS)431549029 /
                      G:(GEPRIS)491111487},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39973495},
      UT           = {WOS:001465166800001},
      doi          = {10.1177/1877718X241310726},
      url          = {https://juser.fz-juelich.de/record/1035306},
}