Journal Article

FZJ-2025-00364

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Non-Motor symptoms in prodromalParkinson’s disease are linked to reducedQuality of Life

Röttgen, S. (Corresponding author)FZJ* ; Fink, G. R.FZJ* ; Sommerauer, M.FZJ* ; Anja, O. ; Doppler, C.FZJ* ; Aline, S.

2025
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.1177/1877718X241310726  doi:10.34734/FZJ-2025-00364

Abstract: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) highlights an early α-synucleinopathy. This study compared health-related quality of life (hrQoL) in 62 individuals with iRBD with 19 healthy controls (HC) and 29 individuals with Parkinson's disease (PD) and identified factors linked to poorer hrQoL. HrQoL was significantly lower in individuals with iRBD (83.33 ± 16.96) compared to HC (92.29 ± 5.49, p = 0.027). Poorer hrQoL in individuals with iRBD was linked to severity of multiple non-motor symptoms, most prominently fatigue and depressive symptoms being significant predictors (p < 0.001, adjusted R2 = 0.81). This study highlights the importance of non-motor symptoms for hrQoL in prodromal PD.

Note: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: C.E.J.D. is supported by the Clinician Scientist Program (CCSP), funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, FI 773/15-1). G.R.F. receives grants from Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Project-ID 431549029, SFB 1451. A.O. received a grant from the Koeln Fortune Program (grant-no. 329/2021), Faculty of Medicine, University of Cologne, and the “Novartis-Stiftung für therapeutische Forschung”, both outside the submitted work. M.S. received grants from the Else Kröner-Fresenius-Stiftung (grant number 2019_EKES.02), and the Koeln Fortune Program, Faculty of Medicine, University of Cologne. M.S. receives additional funding from the program “Netzwerke 2021”, an initiative of the Ministry of Culture and Science of the State of Northrhine Westphalia. The Federal Ministry of Education and Research (BMBF) is funding the project within the framework of the funding programme ACCENT (funding code 01EO2107). Open access publication was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 491111487.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)
2. DFG project G:(GEPRIS)431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029) (431549029)
3. DFG project G:(GEPRIS)491111487 - Open-Access-Publikationskosten / 2025 - 2027 / Forschungszentrum Jülich (OAPKFZJ) (491111487) (491111487)

Appears in the scientific report 2025

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