%0 Journal Article
%A Peinado, Rafaela dos Santos
%A Saivish, Marielena Vogel
%A Menezes, Gabriela de Lima
%A Fulco, Umberto Laino
%A da Silva, Roosevelt Alves
%A Korostov, Karolina
%A Eberle, Raphael Josef
%A Melo, Paulo A.
%A Nogueira, Maurício Lacerda
%A Pacca, Carolina Colombelli
%A Arni, Raghuvir Krishnaswamy
%A Coronado, Mônika Aparecida
%T The search for an antiviral lead molecule to combat the neglected emerging Oropouche virus
%J Current research in microbial sciences
%V 6
%@ 2666-5174
%C Amsterdam
%I Elsevier B.V.
%M FZJ-2025-00503
%P 100238 -
%D 2024
%X Oropouche virus (OROV) is a member of the Peribunyaviridae family and the causative agent of a dengue-like febrile illness transmitted by mosquitoes. Although mild symptoms generally occur, complications such as encephalitis and meningitis may develop. A lack of proper diagnosis, makes it a potential candidate for new epidemics and outbreaks like other known arboviruses such as Dengue, Yellow Fever and Zika virus. The study of natural molecules as potential antiviral compounds is a promising alternative for antiviral therapies. Wedelolactone (WDL) has been demonstrated to inhibit some viral proteins and virus replication, making it useful to target a wide range of viruses. In this study, we report the in silico effects of WDL on the OROV N-terminal polymerase and its potential inhibitory effects on several steps of viral infection in mammalian cells in vitro, which revealed that WDL indeed acts as a potential inhibitor molecule against OROV infection.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 38745914
%U <Go to ISI:>//WOS:001240427000001
%R 10.1016/j.crmicr.2024.100238
%U https://juser.fz-juelich.de/record/1037158