Journal Article

FZJ-2025-00503

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The search for an antiviral lead molecule to combat the neglected emerging Oropouche virus

Peinado, R. d. S. ; Saivish, M. V. ; Menezes, G. d. L. ; Fulco, U. L. ; da Silva, R. A. ; Korostov, K.FZJ* ; Eberle, R. J.FZJ* ; Melo, P. A. ; Nogueira, M. L. ; Pacca, C. C. ; Arni, R. K. ; Coronado, M. A. (Corresponding author)

2024
Elsevier B.V. Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.crmicr.2024.100238  doi:10.34734/FZJ-2025-00503

Abstract: Oropouche virus (OROV) is a member of the Peribunyaviridae family and the causative agent of a dengue-like febrile illness transmitted by mosquitoes. Although mild symptoms generally occur, complications such as encephalitis and meningitis may develop. A lack of proper diagnosis, makes it a potential candidate for new epidemics and outbreaks like other known arboviruses such as Dengue, Yellow Fever and Zika virus. The study of natural molecules as potential antiviral compounds is a promising alternative for antiviral therapies. Wedelolactone (WDL) has been demonstrated to inhibit some viral proteins and virus replication, making it useful to target a wide range of viruses. In this study, we report the in silico effects of WDL on the OROV N-terminal polymerase and its potential inhibitory effects on several steps of viral infection in mammalian cells in vitro, which revealed that WDL indeed acts as a potential inhibitor molecule against OROV infection.

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Contributing Institute(s):

1. Strukturbiochemie (IBI-7)

Research Program(s):

1. 5241 - Molecular Information Processing in Cellular Systems (POF4-524) (POF4-524)

Appears in the scientific report 2024

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