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001037158 1001_ $$00000-0001-5850-6360$$aPeinado, Rafaela dos Santos$$b0
001037158 245__ $$aThe search for an antiviral lead molecule to combat the neglected emerging Oropouche virus
001037158 260__ $$aAmsterdam$$bElsevier B.V.$$c2024
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001037158 520__ $$aOropouche virus (OROV) is a member of the Peribunyaviridae family and the causative agent of a dengue-like febrile illness transmitted by mosquitoes. Although mild symptoms generally occur, complications such as encephalitis and meningitis may develop. A lack of proper diagnosis, makes it a potential candidate for new epidemics and outbreaks like other known arboviruses such as Dengue, Yellow Fever and Zika virus. The study of natural molecules as potential antiviral compounds is a promising alternative for antiviral therapies. Wedelolactone (WDL) has been demonstrated to inhibit some viral proteins and virus replication, making it useful to target a wide range of viruses. In this study, we report the in silico effects of WDL on the OROV N-terminal polymerase and its potential inhibitory effects on several steps of viral infection in mammalian cells in vitro, which revealed that WDL indeed acts as a potential inhibitor molecule against OROV infection.
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001037158 7001_ $$0P:(DE-HGF)0$$aSaivish, Marielena Vogel$$b1
001037158 7001_ $$0P:(DE-HGF)0$$aMenezes, Gabriela de Lima$$b2
001037158 7001_ $$0P:(DE-HGF)0$$aFulco, Umberto Laino$$b3
001037158 7001_ $$0P:(DE-HGF)0$$ada Silva, Roosevelt Alves$$b4
001037158 7001_ $$0P:(DE-Juel1)179345$$aKorostov, Karolina$$b5$$ufzj
001037158 7001_ $$0P:(DE-Juel1)179561$$aEberle, Raphael Josef$$b6$$ufzj
001037158 7001_ $$0P:(DE-HGF)0$$aMelo, Paulo A.$$b7
001037158 7001_ $$0P:(DE-HGF)0$$aNogueira, Maurício Lacerda$$b8
001037158 7001_ $$0P:(DE-HGF)0$$aPacca, Carolina Colombelli$$b9
001037158 7001_ $$0P:(DE-HGF)0$$aArni, Raghuvir Krishnaswamy$$b10
001037158 7001_ $$0P:(DE-Juel1)180738$$aCoronado, Mônika Aparecida$$b11$$eCorresponding author
001037158 773__ $$0PERI:(DE-600)3035226-5$$a10.1016/j.crmicr.2024.100238$$gVol. 6, p. 100238 -$$p100238 -$$tCurrent research in microbial sciences$$v6$$x2666-5174$$y2024
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