TY  - JOUR
AU  - Peinado, Rafaela dos Santos
AU  - Saivish, Marielena Vogel
AU  - Menezes, Gabriela de Lima
AU  - Fulco, Umberto Laino
AU  - da Silva, Roosevelt Alves
AU  - Korostov, Karolina
AU  - Eberle, Raphael Josef
AU  - Melo, Paulo A.
AU  - Nogueira, Maurício Lacerda
AU  - Pacca, Carolina Colombelli
AU  - Arni, Raghuvir Krishnaswamy
AU  - Coronado, Mônika Aparecida
TI  - The search for an antiviral lead molecule to combat the neglected emerging Oropouche virus
JO  - Current research in microbial sciences
VL  - 6
SN  - 2666-5174
CY  - Amsterdam
PB  - Elsevier B.V.
M1  - FZJ-2025-00503
SP  - 100238 -
PY  - 2024
AB  - Oropouche virus (OROV) is a member of the Peribunyaviridae family and the causative agent of a dengue-like febrile illness transmitted by mosquitoes. Although mild symptoms generally occur, complications such as encephalitis and meningitis may develop. A lack of proper diagnosis, makes it a potential candidate for new epidemics and outbreaks like other known arboviruses such as Dengue, Yellow Fever and Zika virus. The study of natural molecules as potential antiviral compounds is a promising alternative for antiviral therapies. Wedelolactone (WDL) has been demonstrated to inhibit some viral proteins and virus replication, making it useful to target a wide range of viruses. In this study, we report the in silico effects of WDL on the OROV N-terminal polymerase and its potential inhibitory effects on several steps of viral infection in mammalian cells in vitro, which revealed that WDL indeed acts as a potential inhibitor molecule against OROV infection.
LB  - PUB:(DE-HGF)16
C6  - 38745914
UR  - <Go to ISI:>//WOS:001240427000001
DO  - DOI:10.1016/j.crmicr.2024.100238
UR  - https://juser.fz-juelich.de/record/1037158
ER  -