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@ARTICLE{Peinado:1037158,
      author       = {Peinado, Rafaela dos Santos and Saivish, Marielena Vogel
                      and Menezes, Gabriela de Lima and Fulco, Umberto Laino and
                      da Silva, Roosevelt Alves and Korostov, Karolina and Eberle,
                      Raphael Josef and Melo, Paulo A. and Nogueira, Maurício
                      Lacerda and Pacca, Carolina Colombelli and Arni, Raghuvir
                      Krishnaswamy and Coronado, Mônika Aparecida},
      title        = {{T}he search for an antiviral lead molecule to combat the
                      neglected emerging {O}ropouche virus},
      journal      = {Current research in microbial sciences},
      volume       = {6},
      issn         = {2666-5174},
      address      = {Amsterdam},
      publisher    = {Elsevier B.V.},
      reportid     = {FZJ-2025-00503},
      pages        = {100238 -},
      year         = {2024},
      abstract     = {Oropouche virus (OROV) is a member of the Peribunyaviridae
                      family and the causative agent of a dengue-like febrile
                      illness transmitted by mosquitoes. Although mild symptoms
                      generally occur, complications such as encephalitis and
                      meningitis may develop. A lack of proper diagnosis, makes it
                      a potential candidate for new epidemics and outbreaks like
                      other known arboviruses such as Dengue, Yellow Fever and
                      Zika virus. The study of natural molecules as potential
                      antiviral compounds is a promising alternative for antiviral
                      therapies. Wedelolactone (WDL) has been demonstrated to
                      inhibit some viral proteins and virus replication, making it
                      useful to target a wide range of viruses. In this study, we
                      report the in silico effects of WDL on the OROV N-terminal
                      polymerase and its potential inhibitory effects on several
                      steps of viral infection in mammalian cells in vitro, which
                      revealed that WDL indeed acts as a potential inhibitor
                      molecule against OROV infection.},
      cin          = {IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38745914},
      UT           = {WOS:001240427000001},
      doi          = {10.1016/j.crmicr.2024.100238},
      url          = {https://juser.fz-juelich.de/record/1037158},
}