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| 001 | 1037158 | ||
| 005 | 20250203124522.0 | ||
| 024 | 7 | _ | |a 10.1016/j.crmicr.2024.100238 |2 doi |
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| 100 | 1 | _ | |a Peinado, Rafaela dos Santos |0 0000-0001-5850-6360 |b 0 |
| 245 | _ | _ | |a The search for an antiviral lead molecule to combat the neglected emerging Oropouche virus |
| 260 | _ | _ | |a Amsterdam |c 2024 |b Elsevier B.V. |
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| 520 | _ | _ | |a Oropouche virus (OROV) is a member of the Peribunyaviridae family and the causative agent of a dengue-like febrile illness transmitted by mosquitoes. Although mild symptoms generally occur, complications such as encephalitis and meningitis may develop. A lack of proper diagnosis, makes it a potential candidate for new epidemics and outbreaks like other known arboviruses such as Dengue, Yellow Fever and Zika virus. The study of natural molecules as potential antiviral compounds is a promising alternative for antiviral therapies. Wedelolactone (WDL) has been demonstrated to inhibit some viral proteins and virus replication, making it useful to target a wide range of viruses. In this study, we report the in silico effects of WDL on the OROV N-terminal polymerase and its potential inhibitory effects on several steps of viral infection in mammalian cells in vitro, which revealed that WDL indeed acts as a potential inhibitor molecule against OROV infection. |
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| 700 | 1 | _ | |a Saivish, Marielena Vogel |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Menezes, Gabriela de Lima |0 P:(DE-HGF)0 |b 2 |
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| 700 | 1 | _ | |a da Silva, Roosevelt Alves |0 P:(DE-HGF)0 |b 4 |
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| 700 | 1 | _ | |a Coronado, Mônika Aparecida |0 P:(DE-Juel1)180738 |b 11 |e Corresponding author |
| 773 | _ | _ | |a 10.1016/j.crmicr.2024.100238 |g Vol. 6, p. 100238 - |0 PERI:(DE-600)3035226-5 |p 100238 - |t Current research in microbial sciences |v 6 |y 2024 |x 2666-5174 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1037158/files/1-s2.0-S2666517424000208-main.pdf |y OpenAccess |
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