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| Home > Publications database > Simulating tumor-induced angiogenesis in macroscopic systems |
| Home > Publications database > Simulating tumor-induced angiogenesis in macroscopic systems |
| Abstract | FZJ-2025-01065 |
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2024
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Please use a persistent id in citations: doi:10.1016/j.bpj.2023.11.1738
Abstract: To this day, cancer remains an insufficiently understood disease plaguing humanity. Part of the difficulty in treating it lies in the variability of tumor types and the way tumors corrupt their environment. A particularly worrying effect is tumor-induced angiogenesis, in which a hypoxic tumor may secrete growth factors, which leads to branching of nearby blood vessels and subsequent growth in the direction of the tumor. We hereby present our work using cells in silico (CiS), a high performance framework for large-scale tissue simulation previously developed by us. Combining a cellular Potts model and an agent-based layer, CiS is capable of simulating tissues composed of tens of millions of cells, while accurately representing many physical and biological properties. Our long-term goal is to build a cellular digital twin of a tumor, and implementing a realistic nutrient environment is a crucial step on this path. We have therefore implemented tumor-induced blood vessel growth into CiS and have studied the behavior of tumors placed in different environments. With this we aim to explore questions regarding “hot spots” for tumor growth within the body.
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