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001041314 1001_ $$0P:(DE-HGF)0$$aKalantari, Aref$$b0
001041314 245__ $$aProportional recovery in mice with cortical stroke
001041314 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2025
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001041314 500__ $$aThis work was funded by the Friebe Foundation (T0498/28960/16) and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project-ID 431549029 – SFB 1451.
001041314 520__ $$aacute stroke patients. However, it still needs to be explored whether the same concept applies to preclinical, i.e.animal models of stroke recovery. To address this question, we investigated behavioral data from 125 adult maleC57Bl/6 J mice with photothrombotic strokes in the sensorimotor cortex. Lesion size and location were determinedin the first week using in vivo T2-weighted MRI. Motor recovery was evaluated repeatedly over four weeksusing the cylinder, grid walk, and rotating beam test. Recovery trajectories were analyzed using a newlyformulated Mouse Recovery Rule (MRR), comparing it against the traditional PRR. Initial findings indicatedvariable recovery patterns, which were separated using a stepwise linear regression approach resulting in twoclusters: 47 % PRR and 53 % MRR. No significant correlation was found between recovery patterns and lesionsize or location, suggesting that other biological factors drive individual differences in recovery. Of note, in theMRR cluster, animals recovered to 90 % of their initial behavioral state within the first four weeks post-stroke,which is higher than the 70 % recovery usually reported in human PRR studies. This study demonstrates thecomplexity of translating the PRR to stroke recovery models in mice and underscores the need for species-specificrecovery models. Our findings have implications for designing and interpreting therapeutic strategies for strokerecovery in preclinical settings, with the potential to improve the predictive accuracy of stroke recoveryassessments.
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001041314 536__ $$0G:(GEPRIS)431549029$$aDFG project G:(GEPRIS)431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029)$$c431549029$$x1
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001041314 7001_ $$0P:(DE-HGF)0$$aHambrock, Carolin$$b1
001041314 7001_ $$0P:(DE-Juel1)161406$$aGrefkes, Christian$$b2
001041314 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b3$$ufzj
001041314 7001_ $$0P:(DE-Juel1)196051$$aAswendt, Markus$$b4$$eCorresponding author
001041314 773__ $$0PERI:(DE-600)1466932-8$$a10.1016/j.expneurol.2025.115180$$gVol. 386, p. 115180 -$$p115180 -$$tExperimental neurology$$v386$$x0014-4886$$y2025
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