Journal Article

FZJ-2025-02213

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Proportional recovery in mice with cortical stroke

Kalantari, A. ; Hambrock, C. ; Grefkes, C. ; Fink, G. R.FZJ* ; Aswendt, M. (Corresponding author)

2025
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.expneurol.2025.115180  doi:10.34734/FZJ-2025-02213

Abstract: acute stroke patients. However, it still needs to be explored whether the same concept applies to preclinical, i.e.animal models of stroke recovery. To address this question, we investigated behavioral data from 125 adult maleC57Bl/6 J mice with photothrombotic strokes in the sensorimotor cortex. Lesion size and location were determinedin the first week using in vivo T2-weighted MRI. Motor recovery was evaluated repeatedly over four weeksusing the cylinder, grid walk, and rotating beam test. Recovery trajectories were analyzed using a newlyformulated Mouse Recovery Rule (MRR), comparing it against the traditional PRR. Initial findings indicatedvariable recovery patterns, which were separated using a stepwise linear regression approach resulting in twoclusters: 47 % PRR and 53 % MRR. No significant correlation was found between recovery patterns and lesionsize or location, suggesting that other biological factors drive individual differences in recovery. Of note, in theMRR cluster, animals recovered to 90 % of their initial behavioral state within the first four weeks post-stroke,which is higher than the 70 % recovery usually reported in human PRR studies. This study demonstrates thecomplexity of translating the PRR to stroke recovery models in mice and underscores the need for species-specificrecovery models. Our findings have implications for designing and interpreting therapeutic strategies for strokerecovery in preclinical settings, with the potential to improve the predictive accuracy of stroke recoveryassessments.

Note: This work was funded by the Friebe Foundation (T0498/28960/16) and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project-ID 431549029 – SFB 1451.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)
2. DFG project G:(GEPRIS)431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029) (431549029)

Appears in the scientific report 2025

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