TY  - JOUR
AU  - Kalantari, Aref
AU  - Hambrock, Carolin
AU  - Grefkes, Christian
AU  - Fink, Gereon R.
AU  - Aswendt, Markus
TI  - Proportional recovery in mice with cortical stroke
JO  - Experimental neurology
VL  - 386
SN  - 0014-4886
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - FZJ-2025-02213
SP  - 115180 -
PY  - 2025
N1  - This work was funded by the Friebe Foundation (T0498/28960/16) and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project-ID 431549029 – SFB 1451.
AB  - acute stroke patients. However, it still needs to be explored whether the same concept applies to preclinical, i.e.animal models of stroke recovery. To address this question, we investigated behavioral data from 125 adult maleC57Bl/6 J mice with photothrombotic strokes in the sensorimotor cortex. Lesion size and location were determinedin the first week using in vivo T2-weighted MRI. Motor recovery was evaluated repeatedly over four weeksusing the cylinder, grid walk, and rotating beam test. Recovery trajectories were analyzed using a newlyformulated Mouse Recovery Rule (MRR), comparing it against the traditional PRR. Initial findings indicatedvariable recovery patterns, which were separated using a stepwise linear regression approach resulting in twoclusters: 47 % PRR and 53 % MRR. No significant correlation was found between recovery patterns and lesionsize or location, suggesting that other biological factors drive individual differences in recovery. Of note, in theMRR cluster, animals recovered to 90 % of their initial behavioral state within the first four weeks post-stroke,which is higher than the 70 % recovery usually reported in human PRR studies. This study demonstrates thecomplexity of translating the PRR to stroke recovery models in mice and underscores the need for species-specificrecovery models. Our findings have implications for designing and interpreting therapeutic strategies for strokerecovery in preclinical settings, with the potential to improve the predictive accuracy of stroke recoveryassessments.
LB  - PUB:(DE-HGF)16
C6  - 39914643
UR  - <Go to ISI:>//WOS:001426315600001
DO  - DOI:10.1016/j.expneurol.2025.115180
UR  - https://juser.fz-juelich.de/record/1041314
ER  -