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@ARTICLE{Kalantari:1041314,
      author       = {Kalantari, Aref and Hambrock, Carolin and Grefkes,
                      Christian and Fink, Gereon R. and Aswendt, Markus},
      title        = {{P}roportional recovery in mice with cortical stroke},
      journal      = {Experimental neurology},
      volume       = {386},
      issn         = {0014-4886},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2025-02213},
      pages        = {115180 -},
      year         = {2025},
      note         = {This work was funded by the Friebe Foundation
                      (T0498/28960/16) and the Deutsche Forschungsgemeinschaft
                      (DFG, German Research Foundation) – Project-ID 431549029
                      – SFB 1451.},
      abstract     = {acute stroke patients. However, it still needs to be
                      explored whether the same concept applies to preclinical,
                      i.e.animal models of stroke recovery. To address this
                      question, we investigated behavioral data from 125 adult
                      maleC57Bl/6 J mice with photothrombotic strokes in the
                      sensorimotor cortex. Lesion size and location were
                      determinedin the first week using in vivo T2-weighted MRI.
                      Motor recovery was evaluated repeatedly over four weeksusing
                      the cylinder, grid walk, and rotating beam test. Recovery
                      trajectories were analyzed using a newlyformulated Mouse
                      Recovery Rule (MRR), comparing it against the traditional
                      PRR. Initial findings indicatedvariable recovery patterns,
                      which were separated using a stepwise linear regression
                      approach resulting in twoclusters: 47 $\%$ PRR and 53 $\%$
                      MRR. No significant correlation was found between recovery
                      patterns and lesionsize or location, suggesting that other
                      biological factors drive individual differences in recovery.
                      Of note, in theMRR cluster, animals recovered to 90 $\%$ of
                      their initial behavioral state within the first four weeks
                      post-stroke,which is higher than the 70 $\%$ recovery
                      usually reported in human PRR studies. This study
                      demonstrates thecomplexity of translating the PRR to stroke
                      recovery models in mice and underscores the need for
                      species-specificrecovery models. Our findings have
                      implications for designing and interpreting therapeutic
                      strategies for strokerecovery in preclinical settings, with
                      the potential to improve the predictive accuracy of stroke
                      recoveryassessments.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / DFG
                      project G:(GEPRIS)431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39914643},
      UT           = {WOS:001426315600001},
      doi          = {10.1016/j.expneurol.2025.115180},
      url          = {https://juser.fz-juelich.de/record/1041314},
}