%0 Journal Article
%A Saberi, Amin
%A Wischnewski, Kevin
%A Jung, Kyesam
%A Lotter, Leon
%A Schaare, H Lina
%A Banaschewski, Tobias
%A Barker, Gareth
%A Bokde, Arun
%A Desrivières, Sylvane
%A Flor, Herta
%A Grigis, Antoine
%A Garavan, Hugh
%A Gowland, Penny
%A Heinz, Andreas
%A Brühl, Rüdiger
%A Martinot, Jean- Luc
%A Martinot, Marie-Laure
%A Artiges, Eric
%A Nees, Frauke
%A Orfanos, Dimitri Papadopoulos
%A Lemaitre, Herve
%A Poustka, Luise
%A Hohmann, Sarah
%A Holz, Nathalie
%A Baeuchl, Christian
%A Smolka, Michael N.
%A Vaidya, Nilakshi
%A Walter, Henrik
%A Whelan, Robert
%A Schumann, Gunter
%A Consortium, IMAGEN
%A Paus, Tomáš
%A Dukart, Juergen
%A Bernhardt, Boris C.
%A Popovych, Oleksandr
%A Eickhoff, Simon
%A Valk, Sofie
%T Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling
%J Science advances
%V 11
%N 23
%@ 2375-2548
%C Washington, DC [u.a.]
%I Assoc.
%M FZJ-2025-02388
%P .
%D 2025
%X The excitation-inhibition ratio is a key functional property of cortical microcircuits which changes throughout an individual’s lifespan. Adolescence is considered a critical period for maturation of excitation-inhibition ratio. This has primarily been observed in animal studies. However, there is limited human in vivo evidence for maturation of excitation-inhibition ratio at the individual level. Here, we developed an individualized in vivo marker of regional excitation-inhibition ratio in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional imaging data from both cross-sectional (n = 752) and longitudinal (n = 149) cohorts. In both datasets, we found a widespread decrease in excitation-inhibition ratio in association areas, paralleled by an increase or lack of change in sensorimotor areas. This developmental pattern was aligned with multiscale markers of sensorimotor-association differentiation. Although our main findings were robust across alternative modeling configurations, we observed local variations, highlighting the importance of methodological choices for future studies.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 40465711
%U <Go to ISI:>//WOS:001507658900013
%R 10.1126/sciadv.adr8164
%U https://juser.fz-juelich.de/record/1041703