Journal Article

FZJ-2025-02388

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling

Saberi, A.FZJ* ; Wischnewski, K.FZJ* ; Jung, K.FZJ* ; Lotter, L.FZJ* ; Schaare, H. L. ; Banaschewski, T. ; Barker, G. ; Bokde, A. ; Desrivières, S. ; Flor, H. ; Grigis, A. ; Garavan, H. ; Gowland, P. ; Heinz, A. ; Brühl, R. ; Martinot, J. L. ; Martinot, M.-L. ; Artiges, E. ; Nees, F. ; Orfanos, D. P. ; Lemaitre, H. ; Poustka, L. ; Hohmann, S. ; Holz, N. ; Baeuchl, C. ; Smolka, M. N. ; Vaidya, N. ; Walter, H. ; Whelan, R. ; Schumann, G. ; Consortium, I. ; Paus, T. ; Dukart, J. ; Bernhardt, B. C. ; Popovych, O.FZJ* ; Eickhoff, S.FZJ* ; Valk, S. (Corresponding author)FZJ*

2025
Assoc. Washington, DC [u.a.]

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Please use a persistent id in citations: doi:10.1126/sciadv.adr8164  doi:10.34734/FZJ-2025-02388

Abstract: The excitation-inhibition ratio is a key functional property of cortical microcircuits which changes throughout an individual’s lifespan. Adolescence is considered a critical period for maturation of excitation-inhibition ratio. This has primarily been observed in animal studies. However, there is limited human in vivo evidence for maturation of excitation-inhibition ratio at the individual level. Here, we developed an individualized in vivo marker of regional excitation-inhibition ratio in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional imaging data from both cross-sectional (n = 752) and longitudinal (n = 149) cohorts. In both datasets, we found a widespread decrease in excitation-inhibition ratio in association areas, paralleled by an increase or lack of change in sensorimotor areas. This developmental pattern was aligned with multiscale markers of sensorimotor-association differentiation. Although our main findings were robust across alternative modeling configurations, we observed local variations, highlighting the importance of methodological choices for future studies.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2025

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