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001041703 1001_ $$0P:(DE-Juel1)190448$$aSaberi, Amin$$b0
001041703 245__ $$aAdolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling
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001041703 520__ $$aThe excitation-inhibition ratio is a key functional property of cortical microcircuits which changes throughout an individual’s lifespan. Adolescence is considered a critical period for maturation of excitation-inhibition ratio. This has primarily been observed in animal studies. However, there is limited human in vivo evidence for maturation of excitation-inhibition ratio at the individual level. Here, we developed an individualized in vivo marker of regional excitation-inhibition ratio in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional imaging data from both cross-sectional (n = 752) and longitudinal (n = 149) cohorts. In both datasets, we found a widespread decrease in excitation-inhibition ratio in association areas, paralleled by an increase or lack of change in sensorimotor areas. This developmental pattern was aligned with multiscale markers of sensorimotor-association differentiation. Although our main findings were robust across alternative modeling configurations, we observed local variations, highlighting the importance of methodological choices for future studies.
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001041703 7001_ $$0P:(DE-HGF)0$$aBanaschewski, Tobias$$b5
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001041703 7001_ $$0P:(DE-HGF)0$$aHeinz, Andreas$$b13
001041703 7001_ $$0P:(DE-HGF)0$$aBrühl, Rüdiger$$b14
001041703 7001_ $$0P:(DE-HGF)0$$aMartinot, Jean- Luc$$b15
001041703 7001_ $$0P:(DE-HGF)0$$aMartinot, Marie-Laure$$b16
001041703 7001_ $$0P:(DE-HGF)0$$aArtiges, Eric$$b17
001041703 7001_ $$0P:(DE-HGF)0$$aNees, Frauke$$b18
001041703 7001_ $$0P:(DE-HGF)0$$aOrfanos, Dimitri Papadopoulos$$b19
001041703 7001_ $$0P:(DE-HGF)0$$aLemaitre, Herve$$b20
001041703 7001_ $$0P:(DE-HGF)0$$aPoustka, Luise$$b21
001041703 7001_ $$0P:(DE-HGF)0$$aHohmann, Sarah$$b22
001041703 7001_ $$0P:(DE-HGF)0$$aHolz, Nathalie$$b23
001041703 7001_ $$0P:(DE-HGF)0$$aBaeuchl, Christian$$b24
001041703 7001_ $$0P:(DE-HGF)0$$aSmolka, Michael N.$$b25
001041703 7001_ $$0P:(DE-HGF)0$$aVaidya, Nilakshi$$b26
001041703 7001_ $$0P:(DE-HGF)0$$aWalter, Henrik$$b27
001041703 7001_ $$0P:(DE-HGF)0$$aWhelan, Robert$$b28
001041703 7001_ $$0P:(DE-HGF)0$$aSchumann, Gunter$$b29
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001041703 7001_ $$0P:(DE-HGF)0$$aBernhardt, Boris C.$$b33
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001041703 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon$$b35$$ufzj
001041703 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie$$b36$$eCorresponding author
001041703 773__ $$0PERI:(DE-600)2810933-8$$a10.1126/sciadv.adr8164$$gVol. 11, no. 23, p. eadr8164$$n23$$p.$$tScience advances$$v11$$x2375-2548$$y2025
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001041703 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)190448$$a Institute of Systems Neuroscience, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.$$b0
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001041703 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)173843$$a Institute of Neuroscience and Medicine - Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany. Institute of Systems Neuroscience, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.$$b36
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