TY  - JOUR
AU  - Saberi, Amin
AU  - Wischnewski, Kevin
AU  - Jung, Kyesam
AU  - Lotter, Leon
AU  - Schaare, H Lina
AU  - Banaschewski, Tobias
AU  - Barker, Gareth
AU  - Bokde, Arun
AU  - Desrivières, Sylvane
AU  - Flor, Herta
AU  - Grigis, Antoine
AU  - Garavan, Hugh
AU  - Gowland, Penny
AU  - Heinz, Andreas
AU  - Brühl, Rüdiger
AU  - Martinot, Jean- Luc
AU  - Martinot, Marie-Laure
AU  - Artiges, Eric
AU  - Nees, Frauke
AU  - Orfanos, Dimitri Papadopoulos
AU  - Lemaitre, Herve
AU  - Poustka, Luise
AU  - Hohmann, Sarah
AU  - Holz, Nathalie
AU  - Baeuchl, Christian
AU  - Smolka, Michael N.
AU  - Vaidya, Nilakshi
AU  - Walter, Henrik
AU  - Whelan, Robert
AU  - Schumann, Gunter
AU  - Consortium, IMAGEN
AU  - Paus, Tomáš
AU  - Dukart, Juergen
AU  - Bernhardt, Boris C.
AU  - Popovych, Oleksandr
AU  - Eickhoff, Simon
AU  - Valk, Sofie
TI  - Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling
JO  - Science advances
VL  - 11
IS  - 23
SN  - 2375-2548
CY  - Washington, DC [u.a.]
PB  - Assoc.
M1  - FZJ-2025-02388
SP  - .
PY  - 2025
AB  - The excitation-inhibition ratio is a key functional property of cortical microcircuits which changes throughout an individual’s lifespan. Adolescence is considered a critical period for maturation of excitation-inhibition ratio. This has primarily been observed in animal studies. However, there is limited human in vivo evidence for maturation of excitation-inhibition ratio at the individual level. Here, we developed an individualized in vivo marker of regional excitation-inhibition ratio in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional imaging data from both cross-sectional (n = 752) and longitudinal (n = 149) cohorts. In both datasets, we found a widespread decrease in excitation-inhibition ratio in association areas, paralleled by an increase or lack of change in sensorimotor areas. This developmental pattern was aligned with multiscale markers of sensorimotor-association differentiation. Although our main findings were robust across alternative modeling configurations, we observed local variations, highlighting the importance of methodological choices for future studies.
LB  - PUB:(DE-HGF)16
C6  - 40465711
UR  - <Go to ISI:>//WOS:001507658900013
DO  - DOI:10.1126/sciadv.adr8164
UR  - https://juser.fz-juelich.de/record/1041703
ER  -