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@ARTICLE{Saberi:1041703,
      author       = {Saberi, Amin and Wischnewski, Kevin and Jung, Kyesam and
                      Lotter, Leon and Schaare, H Lina and Banaschewski, Tobias
                      and Barker, Gareth and Bokde, Arun and Desrivières, Sylvane
                      and Flor, Herta and Grigis, Antoine and Garavan, Hugh and
                      Gowland, Penny and Heinz, Andreas and Brühl, Rüdiger and
                      Martinot, Jean- Luc and Martinot, Marie-Laure and Artiges,
                      Eric and Nees, Frauke and Orfanos, Dimitri Papadopoulos and
                      Lemaitre, Herve and Poustka, Luise and Hohmann, Sarah and
                      Holz, Nathalie and Baeuchl, Christian and Smolka, Michael N.
                      and Vaidya, Nilakshi and Walter, Henrik and Whelan, Robert
                      and Schumann, Gunter and Consortium, IMAGEN and Paus,
                      Tomáš and Dukart, Juergen and Bernhardt, Boris C. and
                      Popovych, Oleksandr and Eickhoff, Simon and Valk, Sofie},
      title        = {{A}dolescent maturation of cortical excitation-inhibition
                      ratio based on individualized biophysical network modeling},
      journal      = {Science advances},
      volume       = {11},
      number       = {23},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {FZJ-2025-02388},
      pages        = {.},
      year         = {2025},
      abstract     = {The excitation-inhibition ratio is a key functional
                      property of cortical microcircuits which changes throughout
                      an individual’s lifespan. Adolescence is considered a
                      critical period for maturation of excitation-inhibition
                      ratio. This has primarily been observed in animal studies.
                      However, there is limited human in vivo evidence for
                      maturation of excitation-inhibition ratio at the individual
                      level. Here, we developed an individualized in vivo marker
                      of regional excitation-inhibition ratio in human
                      adolescents, estimated using large-scale simulations of
                      biophysical network models fitted to resting-state
                      functional imaging data from both cross-sectional (n = 752)
                      and longitudinal (n = 149) cohorts. In both datasets, we
                      found a widespread decrease in excitation-inhibition ratio
                      in association areas, paralleled by an increase or lack of
                      change in sensorimotor areas. This developmental pattern was
                      aligned with multiscale markers of sensorimotor-association
                      differentiation. Although our main findings were robust
                      across alternative modeling configurations, we observed
                      local variations, highlighting the importance of
                      methodological choices for future studies.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40465711},
      UT           = {WOS:001507658900013},
      doi          = {10.1126/sciadv.adr8164},
      url          = {https://juser.fz-juelich.de/record/1041703},
}