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| 024 | 7 | _ | |a 10.1126/sciadv.adr8164 |2 doi |
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| 100 | 1 | _ | |a Saberi, Amin |0 P:(DE-Juel1)190448 |b 0 |
| 245 | _ | _ | |a Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling |
| 260 | _ | _ | |a Washington, DC [u.a.] |c 2025 |b Assoc. |
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| 520 | _ | _ | |a The excitation-inhibition ratio is a key functional property of cortical microcircuits which changes throughout an individual’s lifespan. Adolescence is considered a critical period for maturation of excitation-inhibition ratio. This has primarily been observed in animal studies. However, there is limited human in vivo evidence for maturation of excitation-inhibition ratio at the individual level. Here, we developed an individualized in vivo marker of regional excitation-inhibition ratio in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional imaging data from both cross-sectional (n = 752) and longitudinal (n = 149) cohorts. In both datasets, we found a widespread decrease in excitation-inhibition ratio in association areas, paralleled by an increase or lack of change in sensorimotor areas. This developmental pattern was aligned with multiscale markers of sensorimotor-association differentiation. Although our main findings were robust across alternative modeling configurations, we observed local variations, highlighting the importance of methodological choices for future studies. |
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| 773 | _ | _ | |a 10.1126/sciadv.adr8164 |g Vol. 11, no. 23, p. eadr8164 |0 PERI:(DE-600)2810933-8 |n 23 |p . |t Science advances |v 11 |y 2025 |x 2375-2548 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1041703/files/APC600658990.pdf |
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