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001042420 1001_ $$0P:(DE-HGF)0$$aWang, Yezhou$$b0$$eCorresponding author
001042420 245__ $$aMultimodal gradients unify local and global cortical organization
001042420 260__ $$a[London]$$bSpringer Nature$$c2025
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001042420 520__ $$aFunctional specialization of brain areas and subregions, as well as their integration into large-scale networks, are key principles in neuroscience. Consolidating both local and global perspectives on cortical organization, however, remains challenging. Here, we present an approach to integrate inter- and intra-areal similarities of microstructure, structural connectivity, and functional interactions. Using high-field in-vivo 7 tesla (7 T) Magnetic Resonance Imaging (MRI) data and a probabilistic post-mortem atlas of cortical cytoarchitecture, we derive multimodal gradients that capture cortex-wide organization. Inter-areal similarities follow a canonical sensory-fugal gradient, linking cortical integration with functional diversity across tasks. However, intra-areal heterogeneity does not follow this pattern, with greater variability in association cortices. Findings are replicated in an independent 7 T dataset and a 100-subject 3 tesla (3 T) cohort. These results highlight a robust coupling between local arealization and global cortical motifs, advancing our understanding of how specialization and integration shape human brain function.
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001042420 7001_ $$0P:(DE-Juel1)187055$$aPaquola, Casey$$b2$$ufzj
001042420 7001_ $$00000-0002-2917-1212$$aRodriguez-Cruces, Raul$$b3
001042420 7001_ $$aDeKraker, Jordan$$b4
001042420 7001_ $$00000-0002-4448-8998$$aRoyer, Jessica$$b5
001042420 7001_ $$aCabalo, Donna Gift$$b6
001042420 7001_ $$00000-0003-2127-4636$$aAuer, Hans$$b7
001042420 7001_ $$aNgo, Alexander$$b8
001042420 7001_ $$aLeppert, Ilana R.$$b9
001042420 7001_ $$aTardif, Christine L.$$b10
001042420 7001_ $$aRudko, David A.$$b11
001042420 7001_ $$00000-0002-5801-6318$$aLeech, Robert$$b12
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001042420 7001_ $$00000-0002-7298-2459$$aSmallwood, Jonathan$$b15
001042420 7001_ $$00000-0003-3841-6098$$aEvans, Alan C.$$b16
001042420 7001_ $$00000-0001-9256-6041$$aBernhardt, Boris C.$$b17
001042420 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-59177-4$$gVol. 16, no. 1, p. 3911$$n1$$p3911$$tNature Communications$$v16$$x2041-1723$$y2025
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