Journal Article

FZJ-2025-02568

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Multimodal gradients unify local and global cortical organization

Wang, Y. (Corresponding author) ; Eichert, N. ; Paquola, C.FZJ* ; Rodriguez-Cruces, R. ; DeKraker, J. ; Royer, J. ; Cabalo, D. G. ; Auer, H. ; Ngo, A. ; Leppert, I. R. ; Tardif, C. L. ; Rudko, D. A. ; Leech, R. ; Amunts, K.FZJ* ; Valk, S.FZJ* ; Smallwood, J. ; Evans, A. C. ; Bernhardt, B. C.

2025
Springer Nature [London]

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Please use a persistent id in citations: doi:10.1038/s41467-025-59177-4  doi:10.34734/FZJ-2025-02568

Abstract: Functional specialization of brain areas and subregions, as well as their integration into large-scale networks, are key principles in neuroscience. Consolidating both local and global perspectives on cortical organization, however, remains challenging. Here, we present an approach to integrate inter- and intra-areal similarities of microstructure, structural connectivity, and functional interactions. Using high-field in-vivo 7 tesla (7 T) Magnetic Resonance Imaging (MRI) data and a probabilistic post-mortem atlas of cortical cytoarchitecture, we derive multimodal gradients that capture cortex-wide organization. Inter-areal similarities follow a canonical sensory-fugal gradient, linking cortical integration with functional diversity across tasks. However, intra-areal heterogeneity does not follow this pattern, with greater variability in association cortices. Findings are replicated in an independent 7 T dataset and a 100-subject 3 tesla (3 T) cohort. These results highlight a robust coupling between local arealization and global cortical motifs, advancing our understanding of how specialization and integration shape human brain function.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
2. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. HIBALL - Helmholtz International BigBrain Analytics and Learning Laboratory (HIBALL) (InterLabs-0015) (InterLabs-0015)
3. EBRAINS 2.0 - EBRAINS 2.0: A Research Infrastructure to Advance Neuroscience and Brain Health (101147319) (101147319)

Appears in the scientific report 2025

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