TY  - JOUR
AU  - Wang, Yezhou
AU  - Eichert, Nicole
AU  - Paquola, Casey
AU  - Rodriguez-Cruces, Raul
AU  - DeKraker, Jordan
AU  - Royer, Jessica
AU  - Cabalo, Donna Gift
AU  - Auer, Hans
AU  - Ngo, Alexander
AU  - Leppert, Ilana R.
AU  - Tardif, Christine L.
AU  - Rudko, David A.
AU  - Leech, Robert
AU  - Amunts, Katrin
AU  - Valk, Sofie
AU  - Smallwood, Jonathan
AU  - Evans, Alan C.
AU  - Bernhardt, Boris C.
TI  - Multimodal gradients unify local and global cortical organization
JO  - Nature Communications
VL  - 16
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Springer Nature
M1  - FZJ-2025-02568
SP  - 3911
PY  - 2025
AB  - Functional specialization of brain areas and subregions, as well as their integration into large-scale networks, are key principles in neuroscience. Consolidating both local and global perspectives on cortical organization, however, remains challenging. Here, we present an approach to integrate inter- and intra-areal similarities of microstructure, structural connectivity, and functional interactions. Using high-field in-vivo 7 tesla (7 T) Magnetic Resonance Imaging (MRI) data and a probabilistic post-mortem atlas of cortical cytoarchitecture, we derive multimodal gradients that capture cortex-wide organization. Inter-areal similarities follow a canonical sensory-fugal gradient, linking cortical integration with functional diversity across tasks. However, intra-areal heterogeneity does not follow this pattern, with greater variability in association cortices. Findings are replicated in an independent 7 T dataset and a 100-subject 3 tesla (3 T) cohort. These results highlight a robust coupling between local arealization and global cortical motifs, advancing our understanding of how specialization and integration shape human brain function.
LB  - PUB:(DE-HGF)16
C6  - 40280959
UR  - <Go to ISI:>//WOS:001476786100005
DO  - DOI:10.1038/s41467-025-59177-4
UR  - https://juser.fz-juelich.de/record/1042420
ER  -