Poster (After Call)

FZJ-2025-02823

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Simulating tumor-induced angiogenesis using Cells in Silico

Behle, E. (Corresponding author)FZJ* ; Herold, J. M. ; Schug, A.FZJ*

2024

Abstract: Cancer remains an inadequately understood ailment affecting humanity. Its treatment poses a challenge due to tumor variability and a tumor’s impact on the surrounding environment. Tumor-induced angiogenesis is a concerning aspect of the disease. Here, a hypoxic tumor secretes growth factors, which prompts nearby blood vessel branching and successive growth toward the tumor. To study this process on a computational level, we turned to Cells in Silico (CiS), a high performance framework for large-scale tissue simulation previously developed by us. Combining a cellular Potts model and an agent-based layer, CiS is capable of simulating tissues composed of tens of millions of cells, while accurately representing many physical and biological properties. Our ultimate objective is to construct a cellular digital twin of a tumor, and integrating a realistically evolving nutrient environment is crucial. Hence, we have implemented tumor-induced blood vessel growth into CiS, and have studied the behavior of tumors placed in different environments. With this we aim to explore questions regarding hot spots for tumor growth within the body.

---

Contributing Institute(s):

1. Jülich Supercomputing Center (JSC)

Research Program(s):

1. 5111 - Domain-Specific Simulation & Data Life Cycle Labs (SDLs) and Research Groups (POF4-511) (POF4-511)
2. PhD no Grant - Doktorand ohne besondere Förderung (PHD-NO-GRANT-20170405) (PHD-NO-GRANT-20170405)

---