TY  - JOUR
AU  - Müller, Laura
AU  - Özdüzenciler, Pelin
AU  - Schedlich-Teufer, Charlotte
AU  - Seger, Aline
AU  - Jergas, Hannah
AU  - Fink, Gereon R.
AU  - Willbold, Dieter
AU  - Sommerauer, Michael
AU  - Barbe, Michael T.
AU  - Tamgüney, Gültekin
TI  - Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease
JO  - Annals of neurology
VL  - 98
IS  - 1
SN  - 0364-5134
CY  - Hoboken, NJ
PB  - Wiley-Blackwell
M1  - FZJ-2025-02881
SP  - 147 - 151
PY  - 2025
AB  - Parkinson's disease (PD) is a neurodegenerative disorder characterized by α‐synuclein aggregation in neurons. Recent advances suggest α‐synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used surface‐based fluorescence intensity distribution analysis (sFIDA) to measure α‐synuclein aggregates in urine. Patients with PD and isolated rapid eye movement sleep behavior disorder, a precursor to PD, had elevated concentrations compared with healthy controls. Sensitivity and specificity were 83% and 65% for PD versus controls and 89% and 62% for isolated rapid eye movement sleep behavior disorder versus controls. The findings highlight sFIDA's potential for diagnosing synucleinopathies. ANN NEUROL 2025;98:147–151
LB  - PUB:(DE-HGF)16
C6  - 40285625
UR  - <Go to ISI:>//WOS:001475946300001
DO  - DOI:10.1002/ana.27250
UR  - https://juser.fz-juelich.de/record/1043478
ER  -