Journal Article

FZJ-2025-02881

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease

Müller, L.FZJ* ; Özdüzenciler, P.FZJ* ; Schedlich-Teufer, C. ; Seger, A.FZJ* ; Jergas, H. ; Fink, G. R.FZJ* ; Willbold, D.FZJ* ; Sommerauer, M.FZJ* ; Barbe, M. T. ; Tamgüney, G. (Corresponding author)FZJ*

2025
Wiley-Blackwell Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/ana.27250  doi:10.34734/FZJ-2025-02881

Abstract: Parkinson's disease (PD) is a neurodegenerative disorder characterized by α‐synuclein aggregation in neurons. Recent advances suggest α‐synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used surface‐based fluorescence intensity distribution analysis (sFIDA) to measure α‐synuclein aggregates in urine. Patients with PD and isolated rapid eye movement sleep behavior disorder, a precursor to PD, had elevated concentrations compared with healthy controls. Sensitivity and specificity were 83% and 65% for PD versus controls and 89% and 62% for isolated rapid eye movement sleep behavior disorder versus controls. The findings highlight sFIDA's potential for diagnosing synucleinopathies. ANN NEUROL 2025;98:147–151

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Contributing Institute(s):

1. Strukturbiochemie (IBI-7)
2. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5244 - Information Processing in Neuronal Networks (POF4-524) (POF4-524)

Appears in the scientific report 2025

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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