TY  - JOUR
AU  - Hesse, Robert
AU  - Gertzen, Christoph G. W.
AU  - Schmuck, Jessica Felice
AU  - Böcker, Justin Darvin
AU  - Pandey, Piyush
AU  - Behn, Tobias
AU  - Ruth, Christopher
AU  - Riesner, Detlev
AU  - Kath-Schorr, Stephanie
AU  - Lang, Philipp A.
AU  - Gohlke, Holger
AU  - Etzkorn, Manuel
TI  - The coming of age of DNA‐based catalysts for therapeutic applications
JO  - Clinical and translational medicine
VL  - 15
IS  - 7
SN  - 2001-1326
CY  - Hoboken, NJ
PB  - Wiley
M1  - FZJ-2025-03758
SP  - e70408
PY  - 2025
AB  - DNA enzymes, also known as DNAzymes (Dz), are synthetic high-precision biocatalysts that have been identified by in vitro selection three decades ago.1 Dz are usually short, single-stranded DNA molecules that catalyse chemical reactions through their specific three-dimensional structure.2 Due to their enormous therapeutic potential, particular interest has been invested in RNA-cleaving Dz, such as the 8–17 Dz and 10–23 Dz2. In general, these DNAzymes share a modular architecture comprising a (conserved) catalytic loop sequence and adaptable substrate binding arm sequences that, following specific design guidelines, can be modified to bind virtually any given target RNA with high selectivity.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1002/ctm2.70408
UR  - https://juser.fz-juelich.de/record/1046238
ER  -