Journal Article

FZJ-2025-03758

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The coming of age of DNA‐based catalysts for therapeutic applications

Hesse, R. ; Gertzen, C. G. W. ; Schmuck, J. F.FZJ* ; Böcker, J. D. ; Pandey, P. ; Behn, T. ; Ruth, C. ; Riesner, D. ; Kath-Schorr, S. (Corresponding author) ; Lang, P. A. (Corresponding author) ; Gohlke, H. (Corresponding author)FZJ* ; Etzkorn, M. (Corresponding author)FZJ*

2025
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/ctm2.70408  doi:10.34734/FZJ-2025-03758

Abstract: DNA enzymes, also known as DNAzymes (Dz), are synthetic high-precision biocatalysts that have been identified by in vitro selection three decades ago.1 Dz are usually short, single-stranded DNA molecules that catalyse chemical reactions through their specific three-dimensional structure.2 Due to their enormous therapeutic potential, particular interest has been invested in RNA-cleaving Dz, such as the 8–17 Dz and 10–23 Dz2. In general, these DNAzymes share a modular architecture comprising a (conserved) catalytic loop sequence and adaptable substrate binding arm sequences that, following specific design guidelines, can be modified to bind virtually any given target RNA with high selectivity.

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Contributing Institute(s):

1. Bioinformatik (IBG-4)
2. Strukturbiochemie (IBI-7)

Research Program(s):

1. 2171 - Biological and environmental resources for sustainable use (POF4-217) (POF4-217)
2. 5241 - Molecular Information Processing in Cellular Systems (POF4-524) (POF4-524)

Appears in the scientific report 2025

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