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@ARTICLE{Hesse:1046238,
      author       = {Hesse, Robert and Gertzen, Christoph G. W. and Schmuck,
                      Jessica Felice and Böcker, Justin Darvin and Pandey, Piyush
                      and Behn, Tobias and Ruth, Christopher and Riesner, Detlev
                      and Kath-Schorr, Stephanie and Lang, Philipp A. and Gohlke,
                      Holger and Etzkorn, Manuel},
      title        = {{T}he coming of age of {DNA}‐based catalysts for
                      therapeutic applications},
      journal      = {Clinical and translational medicine},
      volume       = {15},
      number       = {7},
      issn         = {2001-1326},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {FZJ-2025-03758},
      pages        = {e70408},
      year         = {2025},
      abstract     = {DNA enzymes, also known as DNAzymes (Dz), are synthetic
                      high-precision biocatalysts that have been identified by in
                      vitro selection three decades ago.1 Dz are usually short,
                      single-stranded DNA molecules that catalyse chemical
                      reactions through their specific three-dimensional
                      structure.2 Due to their enormous therapeutic potential,
                      particular interest has been invested in RNA-cleaving Dz,
                      such as the 8–17 Dz and 10–23 Dz2. In general, these
                      DNAzymes share a modular architecture comprising a
                      (conserved) catalytic loop sequence and adaptable substrate
                      binding arm sequences that, following specific design
                      guidelines, can be modified to bind virtually any given
                      target RNA with high selectivity.},
      cin          = {IBG-4 / IBI-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBG-4-20200403 / I:(DE-Juel1)IBI-7-20200312},
      pnm          = {2171 - Biological and environmental resources for
                      sustainable use (POF4-217) / 5241 - Molecular Information
                      Processing in Cellular Systems (POF4-524)},
      pid          = {G:(DE-HGF)POF4-2171 / G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40660744},
      UT           = {WOS:001528967100001},
      doi          = {10.1002/ctm2.70408},
      url          = {https://juser.fz-juelich.de/record/1046238},
}