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001     1046238
005     20250930132710.0
024 7 _ |a 10.1002/ctm2.70408
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100 1 _ |a Hesse, Robert
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245 _ _ |a The coming of age of DNA‐based catalysts for therapeutic applications
260 _ _ |a Hoboken, NJ
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520 _ _ |a DNA enzymes, also known as DNAzymes (Dz), are synthetic high-precision biocatalysts that have been identified by in vitro selection three decades ago.1 Dz are usually short, single-stranded DNA molecules that catalyse chemical reactions through their specific three-dimensional structure.2 Due to their enormous therapeutic potential, particular interest has been invested in RNA-cleaving Dz, such as the 8–17 Dz and 10–23 Dz2. In general, these DNAzymes share a modular architecture comprising a (conserved) catalytic loop sequence and adaptable substrate binding arm sequences that, following specific design guidelines, can be modified to bind virtually any given target RNA with high selectivity.
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700 1 _ |a Gertzen, Christoph G. W.
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700 1 _ |a Schmuck, Jessica Felice
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700 1 _ |a Böcker, Justin Darvin
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700 1 _ |a Pandey, Piyush
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700 1 _ |a Behn, Tobias
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700 1 _ |a Ruth, Christopher
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700 1 _ |a Riesner, Detlev
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700 1 _ |a Kath-Schorr, Stephanie
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700 1 _ |a Lang, Philipp A.
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700 1 _ |a Gohlke, Holger
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700 1 _ |a Etzkorn, Manuel
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773 _ _ |a 10.1002/ctm2.70408
|g Vol. 15, no. 7, p. e70408
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856 4 _ |u https://juser.fz-juelich.de/record/1046238/files/Clinical%20Translational%20Med%20-%202025%20-%20Hesse%20-%20The%20coming%20of%20age%20of%20DNA%E2%80%90based%20catalysts%20for%20therapeutic%20applications.pdf
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