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@INPROCEEDINGS{Lang:1047456,
      author       = {Lang, Peter R. and Rivera Moran, Jose Alejandro},
      title        = {{A}nalysing the {E}ffect of {N}oise on {S}tatic and
                      {D}ynamic {R}esults from {T}otal {I}nternal {R}eflection
                      {M}icroscopy ({TIRM})},
      reportid     = {FZJ-2025-04319},
      year         = {2025},
      abstract     = {Total internal reflection microscopy (TIRM) has been used
                      for about 30 years to measure interaction potentials between
                      suspended spherical colloids and flat surfaces. The method
                      also allows measuring position resolved dynamic properties,
                      specifically the diffusion coefficient and the drift
                      velocity normal to the surface. However, in literature there
                      are reports on dynamic results which are at conflict with
                      expectations from standard hydrodynamics. In this work, we
                      have used experimental TIRM in conjunction with molecular
                      dynamics simulations to investigate the effects of inherent
                      error sources due to noise artifacts on TIRM results. We
                      find that detector shot noise and too long sampling times
                      may cause erroneous results in the steep parts of the
                      interaction potential. Further, the noise does not
                      significantly affect dynamic data, but we find that too long
                      sampling times and/or too small probe particles will cause
                      issues. Additionally, we observe that dynamic results are
                      very likely to differ from the standard hydrodynamic
                      predictions for stick boundary conditions. Thus, to minimize
                      experimental errors, sampling times and particle sizes have
                      to be properly chosen when designing TIRM experiments and
                      for the analysis of dynamic information, partial slip
                      conditions have to be considered.},
      month         = {Sep},
      date          = {2025-09-28},
      organization  = {9th International Soft Matter
                       Conference, Platanias (Greece), 28 Sep
                       2025 - 3 Oct 2025},
      subtyp        = {After Call},
      cin          = {IBI-4},
      cid          = {I:(DE-Juel1)IBI-4-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)6},
      doi          = {10.34734/FZJ-2025-04319},
      url          = {https://juser.fz-juelich.de/record/1047456},
}