TY  - CONF
AU  - Schiffer, Christian
AU  - Spitzer, Hannah
AU  - Kropp, Jan-Oliver
AU  - Thönnissen, Andre
AU  - Berr, Katja
AU  - Amunts, Katrin
AU  - Boztoprak, Zeynep
AU  - Dickscheid, Timo
TI  - CytoNet: A Foundation Model for the Human Cerebral Cortex - Applications in BigBrain and Beyond
M1  - FZJ-2025-04896
PY  - 2025
AB  - CytoNet: A Foundation Model for the Human Cerebral Cortex - Applications in BigBrain and Beyond 28 Oct 2025, 12:00 15m Langenbeck-Virchow-HausTalk Session 1: Multiscale Data Integration & AI-based ProcessingSpeaker Christian Schiffer (Forschungszentrum Jülich)DescriptionMicroscopic analysis of cytoarchitecture in the human cerebral cortex is essential for understanding the anatomical basis of brain function. We present CytoNet, a foundation model that encodes high-resolution microscopic image patches into expressive feature representations suitable for whole-brain analysis. CytoNet leverages the spatial relationship between anatomical proximity and microstructural similarity to learn biologically meaningful features using self-supervised learning, without the need for manual annotations. The learned features are consistent across regions and subjects, can be computed at arbitrarily dense sampling locations, and support a wide range of neuroscientific analyses. We demonstrate state-of-the-art performance for brain area classification, cortical layer segmentation, morphological parameter estimation, and unsupervised parcellation. As a foundation model, CytoNet provides a unified representation of cortical microarchitecture and establishes a basis for comprehensive analyses of cytoarchitecture and its relationship to other structural and functional principles at the whole-brain level.
T2  - 9th BigBrain Workshop - HIBALL Closing Symposium
CY  - 27 Oct 2025 - 29 Oct 2025, Berlin (Germany)
Y2  - 27 Oct 2025 - 29 Oct 2025
M2  - Berlin, Germany
LB  - PUB:(DE-HGF)6
UR  - https://juser.fz-juelich.de/record/1048781
ER  -