%0 Journal Article
%A Auer, Hans
%A Cabalo, Donna Gift
%A Rodríguez-Cruces, Raúl
%A Benkarim, Oualid
%A Paquola, Casey
%A DeKraker, Jordan
%A Wang, Yezhou
%A Valk, Sofie Louise
%A Bernhardt, Boris C
%A Royer, Jessica
%T From histology to macroscale function in the human amygdala
%J eLife
%V 13
%@ 2050-084X
%C Cambridge
%I eLife Sciences Publications
%M FZJ-2025-05184
%P RP101950
%D 2025
%X The amygdala is a subcortical region in the mesiotemporal lobe that plays a key role in emotional and sensory functions. Conventional neuroimaging experiments treat this structure as a single, uniform entity, but there is ample histological evidence for subregional heterogeneity in microstructure and function. The current study characterized subregional structure-function coupling in the human amygdala, integrating post-mortem histology and in vivo MRI at ultra-high fields. Core to our work was a novel neuroinformatics approach that leveraged multiscale texture analysis as well as non-linear dimensionality reduction techniques to identify salient dimensions of microstructural variation in a 3D post-mortem histological reconstruction of the human amygdala. We observed two axes of subregional variation in this region, describing inferior-superior as well as mediolateral trends in microstructural differentiation that in part recapitulated established atlases of amygdala subnuclei. Translating our approach to in vivo MRI data acquired at 7 Tesla, we could demonstrate the generalizability of these spatial trends across 10 healthy adults. We then cross-referenced microstructural axes with functional blood-oxygen-level dependent (BOLD) signal analysis obtained during task-free conditions, and revealed a close association of structural axes with macroscale functional network embedding, notably the temporo-limbic, default mode, and sensory-motor networks. Our novel multiscale approach consolidates descriptions of amygdala anatomy and function obtained from histological and in vivo imaging techniques.
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.7554/eLife.101950.3
%U https://juser.fz-juelich.de/record/1049092