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@ARTICLE{Auer:1049092,
      author       = {Auer, Hans and Cabalo, Donna Gift and Rodríguez-Cruces,
                      Raúl and Benkarim, Oualid and Paquola, Casey and DeKraker,
                      Jordan and Wang, Yezhou and Valk, Sofie Louise and
                      Bernhardt, Boris C and Royer, Jessica},
      title        = {{F}rom histology to macroscale function in the human
                      amygdala},
      journal      = {eLife},
      volume       = {13},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {FZJ-2025-05184},
      pages        = {RP101950},
      year         = {2025},
      abstract     = {The amygdala is a subcortical region in the mesiotemporal
                      lobe that plays a key role in emotional and sensory
                      functions. Conventional neuroimaging experiments treat this
                      structure as a single, uniform entity, but there is ample
                      histological evidence for subregional heterogeneity in
                      microstructure and function. The current study characterized
                      subregional structure-function coupling in the human
                      amygdala, integrating post-mortem histology and in vivo MRI
                      at ultra-high fields. Core to our work was a novel
                      neuroinformatics approach that leveraged multiscale texture
                      analysis as well as non-linear dimensionality reduction
                      techniques to identify salient dimensions of microstructural
                      variation in a 3D post-mortem histological reconstruction of
                      the human amygdala. We observed two axes of subregional
                      variation in this region, describing inferior-superior as
                      well as mediolateral trends in microstructural
                      differentiation that in part recapitulated established
                      atlases of amygdala subnuclei. Translating our approach to
                      in vivo MRI data acquired at 7 Tesla, we could demonstrate
                      the generalizability of these spatial trends across 10
                      healthy adults. We then cross-referenced microstructural
                      axes with functional blood-oxygen-level dependent (BOLD)
                      signal analysis obtained during task-free conditions, and
                      revealed a close association of structural axes with
                      macroscale functional network embedding, notably the
                      temporo-limbic, default mode, and sensory-motor networks.
                      Our novel multiscale approach consolidates descriptions of
                      amygdala anatomy and function obtained from histological and
                      in vivo imaging techniques.},
      cin          = {INM-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5254 - Neuroscientific Data Analytics and AI
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5254},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.7554/eLife.101950.3},
      url          = {https://juser.fz-juelich.de/record/1049092},
}