Hauptseite > Online First > From histology to macroscale function in the human amygdala > print

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005     20251210085936.0
024 7 _ |a 10.7554/eLife.101950.3
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100 1 _ |a Auer, Hans
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245 _ _ |a From histology to macroscale function in the human amygdala
260 _ _ |a Cambridge
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520 _ _ |a The amygdala is a subcortical region in the mesiotemporal lobe that plays a key role in emotional and sensory functions. Conventional neuroimaging experiments treat this structure as a single, uniform entity, but there is ample histological evidence for subregional heterogeneity in microstructure and function. The current study characterized subregional structure-function coupling in the human amygdala, integrating post-mortem histology and in vivo MRI at ultra-high fields. Core to our work was a novel neuroinformatics approach that leveraged multiscale texture analysis as well as non-linear dimensionality reduction techniques to identify salient dimensions of microstructural variation in a 3D post-mortem histological reconstruction of the human amygdala. We observed two axes of subregional variation in this region, describing inferior-superior as well as mediolateral trends in microstructural differentiation that in part recapitulated established atlases of amygdala subnuclei. Translating our approach to in vivo MRI data acquired at 7 Tesla, we could demonstrate the generalizability of these spatial trends across 10 healthy adults. We then cross-referenced microstructural axes with functional blood-oxygen-level dependent (BOLD) signal analysis obtained during task-free conditions, and revealed a close association of structural axes with macroscale functional network embedding, notably the temporo-limbic, default mode, and sensory-motor networks. Our novel multiscale approach consolidates descriptions of amygdala anatomy and function obtained from histological and in vivo imaging techniques.
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700 1 _ |a Cabalo, Donna Gift
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700 1 _ |a Rodríguez-Cruces, Raúl
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700 1 _ |a Benkarim, Oualid
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700 1 _ |a Paquola, Casey
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700 1 _ |a DeKraker, Jordan
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700 1 _ |a Wang, Yezhou
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700 1 _ |a Valk, Sofie Louise
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700 1 _ |a Bernhardt, Boris C
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700 1 _ |a Royer, Jessica
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773 _ _ |a 10.7554/eLife.101950.3
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910 1 _ |a Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
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