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@ARTICLE{Keller:1052340,
      author       = {Keller, Lara and Lotter, Leon D. and Eickhoff, Claudia R.
                      and Eickhoff, Simon B. and Otten, Katharina and
                      Herpertz-Dahlmann, Beate and Seitz, Jochen},
      title        = {{S}tructural brain alterations in anorexia nervosa: {A}
                      global brain volume and anatomical likelihood estimation
                      ({ALE}) meta-analysis combined with a functional decoding
                      approach},
      journal      = {NeuroImage: Clinical},
      volume       = {na},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2026-00943},
      pages        = {103950},
      year         = {2026},
      abstract     = {Substantial brain volume loss is well-documented during
                      acute anorexia nervosa (AN); however, longitudinal outcomes
                      are unclear. Our comprehensive meta-analysis investigated
                      global and regional structural brain alterations in adult
                      and adolescent individuals with AN by extracting reported
                      brain volume scores and neuroimaging coordinates from the
                      literature. Results showed significant global brain volume
                      reductions in gray matter (GM), white matter (WM), and
                      increases in cerebrospinal fluid (CSF) in acute AN (N = 1130
                      patients; N = 40 papers), gradually improving upon weight
                      rehabilitation. However, even after 1.5 years of recovery,
                      significantly lower global GM volume compared to healthy
                      controls was found (N = 232 patients; N = 12 papers).
                      Regarding potential regional changes, our search identified
                      35 eligible papers with neuroimaging coordinates for 412
                      foci as input for our anatomical likelihood estimation (ALE)
                      analyses. The results revealed widespread reductions of GM
                      volume and cortical thickness, but notably also identified
                      consistently affected brain regions including the cingulate
                      gyrus, precentral gyrus, and precuneus. Spatial
                      colocalization analyses using the Neurosynth data base
                      indicated brain areas associated with eating, food, threat,
                      and reinforcement to be relatively preserved. The findings
                      of our meta-analysis contribute to a better understanding of
                      the underlying pathophysiology of AN, the time course and
                      residuals of brain structural alterations during recovery
                      and clinical implications potentially relevant for
                      more-targeted treatment options.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.nicl.2026.103950},
      url          = {https://juser.fz-juelich.de/record/1052340},
}