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001052783 037__ $$aFZJ-2026-01140
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001052783 1001_ $$aFranz, Marlene$$b0
001052783 245__ $$aOrbitofrontal Thickness and Network Associations as Transdiagnostic Signature of Amotivation Along the Bipolar-Schizophrenia Spectrum
001052783 260__ $$aOxford$$bOxford Univ. Press$$c2025
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001052783 520__ $$aBackground and Hypothesis: Negative symptoms of schiz-ophrenia (SCZ), particularly amotivation, are prominentacross both SCZ and bipolar disorder (BD). While orbit-ofrontal cortex (OFC) alterations have been implicated inthe development of negative symptoms, their contributionsacross disorders remain to be established. Here, we exam-ined how OFC thickness and network associations relate toamotivation compared to diminished expression across theBD-SCZ spectrum.Study Design: We included 50 individuals with SCZ, 49with BD, and 122 controls. We assessed amotivation anddiminished expression and estimated thickness in the me-dial and lateral OFC as regions of interest as well as 64other cortical regions.Study Results: Across BD and SCZ, reduced right lateraland bilateral medial OFC thickness were specifically asso-ciated with amotivation, but not diminished expression orother clinical factors. We then generated intra-individualOFC structural covariance networks to evaluate how thesystem-level embedding of the OFC would link to brain-wide cortical maps of negative symptoms. We found thatmedial OFC covariance networks spatially correlatedwith the brain-wide cortical alterations of both negativesymptom dimensions. Further analyses in independentSCZ data from the ENIGMA consortium (n = 4474) re-vealed associations with lateral OFC covariance networks.Finally, the brain-wide cortical alterations of amotivationwere significantly correlated with normative functional andstructural white-matter connectivity profiles of the rightmedial and left lateral OFC as well as adjacent prefrontaland limbic regions.Conclusions: Our work identifies OFC alterations as a pos-sible transdiagnostic signature of amotivation and providesinsights into network associations underlying the system-wide cortical alterations of negative symptoms across SCZand BD
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001052783 7001_ $$aKebets, Valeria$$b1
001052783 7001_ $$aBerg, Xaver$$b2
001052783 7001_ $$aGeorgiadis, Foivos$$b3
001052783 7001_ $$aMilano, Beatrice A$$b4
001052783 7001_ $$aBurrer, Achim$$b5
001052783 7001_ $$aBrakowski, Janis$$b6
001052783 7001_ $$aKaiser, Stefan$$b7
001052783 7001_ $$aSeifritz, Erich$$b8
001052783 7001_ $$00000-0001-9034-148X$$aHoman, Philipp$$b9
001052783 7001_ $$aWalton, Esther$$b10
001052783 7001_ $$avan Erp, Theo G M$$b11
001052783 7001_ $$aTurner, Jessica A$$b12
001052783 7001_ $$00000-0003-0307-2862$$aMisic, Bratislav$$b13
001052783 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie L$$b14$$ufzj
001052783 7001_ $$aYeo, B T Thomas$$b15
001052783 7001_ $$aBernhardt, Boris C$$b16
001052783 7001_ $$0P:(DE-HGF)0$$aKirschner, Matthias$$b17$$eCorresponding author
001052783 773__ $$0PERI:(DE-600)2180196-4$$a10.1093/schbul/sbaf078$$gp. sbaf078$$psbaf078$$tSchizophrenia bulletin$$v-$$x0586-7614$$y2025
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