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@ARTICLE{Franz:1052783,
      author       = {Franz, Marlene and Kebets, Valeria and Berg, Xaver and
                      Georgiadis, Foivos and Milano, Beatrice A and Burrer, Achim
                      and Brakowski, Janis and Kaiser, Stefan and Seifritz, Erich
                      and Homan, Philipp and Walton, Esther and van Erp, Theo G M
                      and Turner, Jessica A and Misic, Bratislav and Valk, Sofie L
                      and Yeo, B T Thomas and Bernhardt, Boris C and Kirschner,
                      Matthias},
      title        = {{O}rbitofrontal {T}hickness and {N}etwork {A}ssociations as
                      {T}ransdiagnostic {S}ignature of {A}motivation {A}long the
                      {B}ipolar-{S}chizophrenia {S}pectrum},
      journal      = {Schizophrenia bulletin},
      volume       = {-},
      issn         = {0586-7614},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2026-01140},
      pages        = {sbaf078},
      year         = {2025},
      abstract     = {Background and Hypothesis: Negative symptoms of
                      schiz-ophrenia (SCZ), particularly amotivation, are
                      prominentacross both SCZ and bipolar disorder (BD). While
                      orbit-ofrontal cortex (OFC) alterations have been implicated
                      inthe development of negative symptoms, their
                      contributionsacross disorders remain to be established.
                      Here, we exam-ined how OFC thickness and network
                      associations relate toamotivation compared to diminished
                      expression across theBD-SCZ spectrum.Study Design: We
                      included 50 individuals with SCZ, 49with BD, and 122
                      controls. We assessed amotivation anddiminished expression
                      and estimated thickness in the me-dial and lateral OFC as
                      regions of interest as well as 64other cortical
                      regions.Study Results: Across BD and SCZ, reduced right
                      lateraland bilateral medial OFC thickness were specifically
                      asso-ciated with amotivation, but not diminished expression
                      orother clinical factors. We then generated
                      intra-individualOFC structural covariance networks to
                      evaluate how thesystem-level embedding of the OFC would link
                      to brain-wide cortical maps of negative symptoms. We found
                      thatmedial OFC covariance networks spatially correlatedwith
                      the brain-wide cortical alterations of both negativesymptom
                      dimensions. Further analyses in independentSCZ data from the
                      ENIGMA consortium (n = 4474) re-vealed associations with
                      lateral OFC covariance networks.Finally, the brain-wide
                      cortical alterations of amotivationwere significantly
                      correlated with normative functional andstructural
                      white-matter connectivity profiles of the rightmedial and
                      left lateral OFC as well as adjacent prefrontaland limbic
                      regions.Conclusions: Our work identifies OFC alterations as
                      a pos-sible transdiagnostic signature of amotivation and
                      providesinsights into network associations underlying the
                      system-wide cortical alterations of negative symptoms across
                      SCZand BD},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5252 - Brain Dysfunction and Plasticity
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1093/schbul/sbaf078},
      url          = {https://juser.fz-juelich.de/record/1052783},
}