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| Hauptseite > Online First > Orbitofrontal Thickness and Network Associations as Transdiagnostic Signature of Amotivation Along the Bipolar-Schizophrenia Spectrum > print |
| Hauptseite > Online First > Orbitofrontal Thickness and Network Associations as Transdiagnostic Signature of Amotivation Along the Bipolar-Schizophrenia Spectrum > print |
| 001 | 1052783 | ||
| 005 | 20260127132038.0 | ||
| 024 | 7 | _ | |a 10.1093/schbul/sbaf078 |2 doi |
| 024 | 7 | _ | |a 0586-7614 |2 ISSN |
| 024 | 7 | _ | |a 1745-1701 |2 ISSN |
| 037 | _ | _ | |a FZJ-2026-01140 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Franz, Marlene |b 0 |
| 245 | _ | _ | |a Orbitofrontal Thickness and Network Associations as Transdiagnostic Signature of Amotivation Along the Bipolar-Schizophrenia Spectrum |
| 260 | _ | _ | |a Oxford |c 2025 |b Oxford Univ. Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1769513374_17341 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Background and Hypothesis: Negative symptoms of schiz-ophrenia (SCZ), particularly amotivation, are prominentacross both SCZ and bipolar disorder (BD). While orbit-ofrontal cortex (OFC) alterations have been implicated inthe development of negative symptoms, their contributionsacross disorders remain to be established. Here, we exam-ined how OFC thickness and network associations relate toamotivation compared to diminished expression across theBD-SCZ spectrum.Study Design: We included 50 individuals with SCZ, 49with BD, and 122 controls. We assessed amotivation anddiminished expression and estimated thickness in the me-dial and lateral OFC as regions of interest as well as 64other cortical regions.Study Results: Across BD and SCZ, reduced right lateraland bilateral medial OFC thickness were specifically asso-ciated with amotivation, but not diminished expression orother clinical factors. We then generated intra-individualOFC structural covariance networks to evaluate how thesystem-level embedding of the OFC would link to brain-wide cortical maps of negative symptoms. We found thatmedial OFC covariance networks spatially correlatedwith the brain-wide cortical alterations of both negativesymptom dimensions. Further analyses in independentSCZ data from the ENIGMA consortium (n = 4474) re-vealed associations with lateral OFC covariance networks.Finally, the brain-wide cortical alterations of amotivationwere significantly correlated with normative functional andstructural white-matter connectivity profiles of the rightmedial and left lateral OFC as well as adjacent prefrontaland limbic regions.Conclusions: Our work identifies OFC alterations as a pos-sible transdiagnostic signature of amotivation and providesinsights into network associations underlying the system-wide cortical alterations of negative symptoms across SCZand BD |
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| 700 | 1 | _ | |a Kebets, Valeria |b 1 |
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| 700 | 1 | _ | |a Walton, Esther |b 10 |
| 700 | 1 | _ | |a van Erp, Theo G M |b 11 |
| 700 | 1 | _ | |a Turner, Jessica A |b 12 |
| 700 | 1 | _ | |a Misic, Bratislav |0 0000-0003-0307-2862 |b 13 |
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| 700 | 1 | _ | |a Yeo, B T Thomas |b 15 |
| 700 | 1 | _ | |a Bernhardt, Boris C |b 16 |
| 700 | 1 | _ | |a Kirschner, Matthias |0 P:(DE-HGF)0 |b 17 |e Corresponding author |
| 773 | _ | _ | |a 10.1093/schbul/sbaf078 |g p. sbaf078 |0 PERI:(DE-600)2180196-4 |p sbaf078 |t Schizophrenia bulletin |v - |y 2025 |x 0586-7614 |
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