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@INPROCEEDINGS{Kraft:1053912,
      author       = {Kraft, Manuel and Hilgers, Julia and Peplinski, Jana-Marie
                      and Werner, Jan-Michael and Ceccon, Garry and Wollring,
                      Michael and Stetter, Isabelle and Fink, Gereon R and Langen,
                      Karl-Josef and Mottaghy, Felix M and Ciantar, Keith George
                      and Shah, Nadim J and Lohmann, Philipp and Kocher, Martin
                      and Galldiks, Norbert},
      title        = {{IMG}-98. {M}etabolic response using the {PET} {RANO} 1.0
                      criteria following chemoradiation is associated with an
                      increase in functional connectivity},
      issn         = {1523-5866},
      reportid     = {FZJ-2026-01610},
      year         = {2025},
      abstract     = {AbstractBACKGROUNDThe emerging field of Cancer Neuroscience
                      suggests intense structural and functional connections
                      between gliomas and the CNS, leading to large-scale network
                      alterations. Resting-state fMRI (rs-fMRI) offers the option
                      to evaluate functional connectivity (FC) within this complex
                      network. For example, recent data suggest that the integrity
                      of FC obtained from single scans in recurrent gliomas is
                      prognostic in terms of overall survival. In the present
                      study, we evaluated in patients with glioma undergoing
                      treatment whether a metabolic response in
                      O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) PET is also
                      associated with FC improvement using serial
                      rs-fMRI.METHODSForty-five patients with glioma characterized
                      according to the CNS WHO 2021 classification (glioblastoma,
                      n=27; grade 3 or 4 astrocytoma, n=8; grade 2 or 3
                      oligodendroglioma, n=10), were retrospectively identified.
                      Serial rs-fMRI and FET PET were performed using a 3T hybrid
                      PET/MR scanner before and after chemoradiation (n=27),
                      resection (n=9), or during the treatment-free interval at
                      two time points (n=9). The mean time between scans was 6.0
                      months. Metabolic response was assessed using the PET RANO
                      1.0 criteria. FC was assessed by examining the BOLD-activity
                      time course correlations in rs-fMRI within and between seven
                      canonical resting-state networks.RESULTSAt follow-up, FC of
                      brain regions within the limbic resting-state network
                      significantly increased in metabolic responders (n=23)
                      compared to non-responders (n=22) who showed a decrease in
                      FC (p=0.011). In subgroup analyses of the received treatment
                      modality, this change of FC in association with metabolic
                      response was significant only in patients who had received
                      chemoradiation (n=27; p=0.026), whereas in patients who had
                      undergone resection, a similar tendency unveiled (n=9;
                      p=0.053). In contrast, metabolic response was not associated
                      with FC changes in patients during the treatment-free
                      interval (n=9; p=0.459).CONCLUSIONSOur data suggest that FC
                      is restored in metabolic responders following glioma
                      treatment, indicating its predictive potential as imaging
                      marker for response assessment.},
      month         = {Nov},
      date          = {2025-11-20},
      organization  = {7th Quadrennial Meeting of the World
                       Federation of Neuro-Oncology Societies,
                       Honolulu (USA), 20 Nov 2025 - 23 Nov
                       2025},
      cin          = {INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)1},
      doi          = {10.1093/neuonc/noaf201.1177},
      url          = {https://juser.fz-juelich.de/record/1053912},
}