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@ARTICLE{Parlak:1054196,
      author       = {Parlak, Z. V. and Labude-Weber, N. and Krause, Sandra and
                      Neuhaus, Kerstin and Schmidt, Christina and Mueller, Marlene
                      and Radermacher, C. and Ruetten, S. and Henss, A. and
                      Ferraris, S. and Spriano, S. and Neuss, S. and Gonzalez,
                      Jesus and Schickle, K.},
      title        = {{T}he impact of crystallographic plane orientation as an
                      unexplored terrain in hemocompatible material design},
      journal      = {},
      reportid     = {FZJ-2026-01724},
      year         = {2026},
      abstract     = {Thrombogenicity causes significant complications in the
                      application of blood-contactingimplants, requiring
                      strategies to prevent adverse coagulation reactions. The
                      thrombotic re-sponses to the foreign surfaces are mainly
                      driven by surficial factors such as surface
                      energy,topography, and electrochemical interactions.
                      Although anticoagulation therapies reducethe risks of
                      clotting, patients might still encounter bleeding
                      complications. Therefore, ratherthan high-risk
                      anticoagulation therapies to counteract coagulation, it is
                      essential to ensurehemocompatibility through the
                      material’s intrinsic properties. Endothelialization is
                      crucialin preventing thrombotic complications, with various
                      strategies explored for facilitating en-dothelial cell
                      adhesion and proliferation. We investigated the impact of
                      crystallographicanisotropy on endothelial and blood cell
                      interactions on four main planes (A-, C-, M-,and R-planes)
                      of single crystalline alumina (α-Al2O3, sapphire).
                      Employing advanced sur-face characterization techniques,
                      including SIMS, KPFM and Zeta potential measurements,our
                      study sheds light on the hemocompatibility of biomaterials
                      considering anisotropic ef-fects. We elucidated that the
                      A-plane of alumina promotes endothelialization and
                      suppressesplatelet activation in contrast to other
                      crystallographic planes. Our investigation into cell-surface
                      interactions provides valuable insights and contributes to
                      the advanced biomaterialdesign, ultimately leading to
                      enhanced clinical outcomes.},
      cin          = {IMD-4},
      cid          = {I:(DE-Juel1)IMD-4-20141217},
      pnm          = {1221 - Fundamentals and Materials (POF4-122) / DFG project
                      G:(GEPRIS)405895710 - CeramStent2 – Neuartige
                      Keramik-Metall-Beschichtungen für koronare Implantate zur
                      Reduktion lokaler thrombotischer Ereignisse und Verbesserung
                      der Hämokompatibilität, mechanischen Stabilität und
                      chemischen Langzeitbeständigkeit (405895710)},
      pid          = {G:(DE-HGF)POF4-1221 / G:(GEPRIS)405895710},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.64898/2026.01.30.702901},
      url          = {https://juser.fz-juelich.de/record/1054196},
}