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@ARTICLE{Tahmasian:1055237,
      author       = {Tahmasian, Masoud and Elberse, Jorik D. and Ahmadi,
                      Reihaneh and Liu, Wen and Rosenzweig, Ivana and Genon, Sarah
                      and Eickhoff, Simon B. and Mander, Bryce A.},
      title        = {{S}leep disturbances and {A}lzheimer’s disease: a
                      multiscale approach from exposome to neurobiology and
                      precision medicine},
      journal      = {GeroScience},
      volume       = {-},
      issn         = {2509-2715},
      address      = {[Cham]},
      publisher    = {Springer International Publishing},
      reportid     = {FZJ-2026-01880},
      pages        = {-},
      year         = {2026},
      abstract     = {Sleep disturbances and Alzheimer's disease (AD) are
                      interconnected public health challenges. However, the
                      underlying mechanisms of their complex relationships remain
                      elusive. Here, we propose a hypothetical integrative,
                      stream-like model outlining how external and internal
                      exposome factors accelerate brain aging, thereby
                      exacerbating circadian dysregulation, orexin-mediated
                      hyperexcitability, metabolic imbalance, and inflammaging.
                      These changes can lead to increased sleep fragmentation and
                      reduced slow-wave sleep, triggering widespread
                      neuroinflammation, glymphatic dysfunction, and the
                      accumulation and dissemination of beta-amyloid and tau
                      peptides. These processes collectively accelerate synaptic
                      dysfunction, neuronal loss, and cognitive decline. We also
                      highlight recent neuroimaging evidence that elucidates the
                      neural substrates underlying the relationship between poor
                      sleep and AD. Moreover, tackling their shared burden
                      necessitates the active consideration of inter-individual
                      variability in vulnerable populations through artificial
                      intelligence and computational approaches, aligning with the
                      core tenets of precision medicine. We hope this review
                      encourages clinicians to prioritize monitoring and treating
                      sleep disturbances to reduce the incidence, severity, and
                      consequences of dementia in the general population.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5251 -
                      Multilevel Brain Organization and Variability (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1007/s11357-026-02152-8},
      url          = {https://juser.fz-juelich.de/record/1055237},
}