Journal Article

PreJuSER-10808

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Radiochemical determination of nuclear data for therapy and applications

Qaim, S. M.FZJ*

2010
Springer Science + Business Media B.V Dordrecht [u.a.]

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Please use a persistent id in citations: doi:10.1007/s10967-010-0460-5

Abstract: To examine the association between presence of clinically relevant depressive symptoms (Center for Epidemiologic Studies Depression Scale [CES-D] score >or= 16) and subsequent cognitive function (Mini-Mental State Examination [MMSE]) over a 7-year period in older Mexican Americans, a prospective cohort study was performed. Five south-western states contributed data to the Hispanic Established Populations for Epidemiologic Studies of the Elderly. Participants included 2812 noninstitutionalized Mexican Americans aged 65 and older followed from 1993-1994 until 2000-2001. Cognitive change was assessed using the MMSE at baseline and at 2, 5, and 7 years of follow-up. Independent variables were sociodemographics, CES-D >or= 16, medical conditions (hypertension, diabetes, coronary artery disease, and stroke), and activities of daily living (ADL) status. A general linear mixed model was used to estimate cognitive change. There was a cross-sectional association between CES-D >or= 16 and lower MMSE score (estimate = -0.48; standard error [SE] = 0.15; P < .01), independent of age, gender, education, marital status, time of interview, ADL limitations, vision impairment, and medical conditions. In the fully adjusted longitudinal model, subjects with clinically relevant depressive symptoms had a greater decline in MMSE score over 7 years than those without clinically relevant depressive symptoms (estimate = -0.17; SE = 0.05; P < .001), adjusting for sociodemographics, ADL and medical conditions. Each point increase in the CES-D score was associated with a decline of 0.010 point in MMSE score per year (SE = 0.002; P < 0.0001), adjusting for relevant confounders. Presence of clinically relevant depressive symptoms was associated with subsequent decline in cognitive function over 7 years in older Mexican Americans, independent of demographic and health factors.

Keyword(s): Activities of Daily Living (MeSH) ; Aged (MeSH) ; Aging: psychology (MeSH) ; Cognition (MeSH) ; Cognition Disorders: diagnosis (MeSH) ; Cognition Disorders: epidemiology (MeSH) ; Cognition Disorders: psychology (MeSH) ; Cohort Studies (MeSH) ; Depressive Disorder: diagnosis (MeSH) ; Depressive Disorder: epidemiology (MeSH) ; Depressive Disorder: psychology (MeSH) ; Female (MeSH) ; Follow-Up Studies (MeSH) ; Geriatric Assessment: methods (MeSH) ; Geriatric Assessment: statistics & numerical data (MeSH) ; Health Status (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Mexican Americans: psychology (MeSH) ; Mexican Americans: statistics & numerical data (MeSH) ; Prospective Studies (MeSH) ; Psychiatric Status Rating Scales: statistics & numerical data (MeSH) ; Socioeconomic Factors (MeSH) ; J ; Nuclear reactions (auto) ; Nuclear data (auto) ; Radiochemical methods (auto) ; Complex particle emission (auto) ; Isomeric cross section (auto) ; Fusion reactor technology (auto) ; Medical radionuclide production (auto)

Note: The article gives a brief review of the work carried out over a period of more than 35 years at the Institute of Nuclear Chemistry of the Research Centre Julich, Germany. I am highly indebted to Professor Dr. G. Stocklin and Prof. Dr. H. H. Coenen, the former and present directors of the Institute, for their continuous support of this field of study, and to my own research group for painstaking efforts in acquisition and analysis of data. A large number of Ph.D. students and guest scientists also contributed appreciably to our efforts. My special thanks are due to about 10 Hungarian scientists for a long-term and fruitful cooperation both in experimental studies and nuclear model calculations. The partial financial supports of some external funding agencies like DFG, DAAD, EU, IAEA, etc. are gratefully acknowledged.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. 89573 - Neuroimaging (POF2-89573) (POF2-89573)

Appears in the scientific report 2010

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