TY  - JOUR
AU  - Qaim, S. M.
TI  - Radiochemical determination of nuclear data for therapy and applications
JO  - Journal of radioanalytical and nuclear chemistry
VL  - 284
SN  - 0236-5731
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - PreJuSER-10808
SP  - 489 - 505
PY  - 2010
N1  - The article gives a brief review of the work carried out over a period of more than 35 years at the Institute of Nuclear Chemistry of the Research Centre Julich, Germany. I am highly indebted to Professor Dr. G. Stocklin and Prof. Dr. H. H. Coenen, the former and present directors of the Institute, for their continuous support of this field of study, and to my own research group for painstaking efforts in acquisition and analysis of data. A large number of Ph.D. students and guest scientists also contributed appreciably to our efforts. My special thanks are due to about 10 Hungarian scientists for a long-term and fruitful cooperation both in experimental studies and nuclear model calculations. The partial financial supports of some external funding agencies like DFG, DAAD, EU, IAEA, etc. are gratefully acknowledged.
AB  - To examine the association between presence of clinically relevant depressive symptoms (Center for Epidemiologic Studies Depression Scale [CES-D] score >or= 16) and subsequent cognitive function (Mini-Mental State Examination [MMSE]) over a 7-year period in older Mexican Americans, a prospective cohort study was performed. Five south-western states contributed data to the Hispanic Established Populations for Epidemiologic Studies of the Elderly. Participants included 2812 noninstitutionalized Mexican Americans aged 65 and older followed from 1993-1994 until 2000-2001. Cognitive change was assessed using the MMSE at baseline and at 2, 5, and 7 years of follow-up. Independent variables were sociodemographics, CES-D >or= 16, medical conditions (hypertension, diabetes, coronary artery disease, and stroke), and activities of daily living (ADL) status. A general linear mixed model was used to estimate cognitive change. There was a cross-sectional association between CES-D >or= 16 and lower MMSE score (estimate = -0.48; standard error [SE] = 0.15; P < .01), independent of age, gender, education, marital status, time of interview, ADL limitations, vision impairment, and medical conditions. In the fully adjusted longitudinal model, subjects with clinically relevant depressive symptoms had a greater decline in MMSE score over 7 years than those without clinically relevant depressive symptoms (estimate = -0.17; SE = 0.05; P < .001), adjusting for sociodemographics, ADL and medical conditions. Each point increase in the CES-D score was associated with a decline of 0.010 point in MMSE score per year (SE = 0.002; P < 0.0001), adjusting for relevant confounders. Presence of clinically relevant depressive symptoms was associated with subsequent decline in cognitive function over 7 years in older Mexican Americans, independent of demographic and health factors.
KW  - Activities of Daily Living
KW  - Aged
KW  - Aging: psychology
KW  - Cognition
KW  - Cognition Disorders: diagnosis
KW  - Cognition Disorders: epidemiology
KW  - Cognition Disorders: psychology
KW  - Cohort Studies
KW  - Depressive Disorder: diagnosis
KW  - Depressive Disorder: epidemiology
KW  - Depressive Disorder: psychology
KW  - Female
KW  - Follow-Up Studies
KW  - Geriatric Assessment: methods
KW  - Geriatric Assessment: statistics & numerical data
KW  - Health Status
KW  - Humans
KW  - Male
KW  - Mexican Americans: psychology
KW  - Mexican Americans: statistics & numerical data
KW  - Prospective Studies
KW  - Psychiatric Status Rating Scales: statistics & numerical data
KW  - Socioeconomic Factors
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:17712097
UR  - <Go to ISI:>//WOS:000276910200002
DO  - DOI:10.1007/s10967-010-0460-5
UR  - https://juser.fz-juelich.de/record/10808
ER  -