Journal Article

PreJuSER-10891

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Regional impairment of (18)F-FDG uptake in the cervical spinal cord in patients with monosegmental chronic cervical myelopathy

Floeth, F. W. ; Stoffels, G.FZJ* ; Herdmann, J. ; Jansen, P.FZJ* ; Meyer, W.FZJ* ; Steiger, H. J. ; Langen, K.-J.FZJ*

2010
Springer Berlin

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Please use a persistent id in citations: doi:10.1007/s00330-010-1877-5

Abstract: The aim of this preliminary report was to assess glucose metabolism in the cervical spine of patients with chronic compressive myelopathy by using FDG PET.Ten patients with monosegmental chronic degenerative stenosis and local cord compression of the upper/middle cervical spine with signs of myelopathy on MRI and 10 control patients without known cervical abnormalities were investigated by FDG PET. Maximum standardised uptake values (SUV(max)) were measured at all levels of the cervical spine (C1-C7).While the controls showed the typical pattern of homogeneous linear FDG uptake along the entire cervical cord, the patients with chronic compressive myelopathy had a normal glucose utilisation only above the level of stenosis and a significant decrease in FDG uptake below their individual level of cord compression. This may be caused by atrophy of anterior grey horn cells and the loss of glucose-consuming neurons below the level of cord compression.FDG PET of the spine of patients with chronic compressive myelopathy may be helpful to determine the stage and severity of cervical myelopathy.

Keyword(s): Aged (MeSH) ; Aged, 80 and over (MeSH) ; Cervical Vertebrae: metabolism (MeSH) ; Cervical Vertebrae: radionuclide imaging (MeSH) ; Female (MeSH) ; Fluorodeoxyglucose F18: diagnostic use (MeSH) ; Fluorodeoxyglucose F18: pharmacokinetics (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Radiopharmaceuticals: diagnostic use (MeSH) ; Radiopharmaceuticals: pharmacokinetics (MeSH) ; Spinal Cord: metabolism (MeSH) ; Spinal Cord: radionuclide imaging (MeSH) ; Spinal Stenosis: metabolism (MeSH) ; Spinal Stenosis: radionuclide imaging (MeSH) ; Tissue Distribution (MeSH) ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 ; J ; FDG PET (auto) ; Cervical spinal cord (auto) ; Cervical myelopathy (auto) ; Degenerative spinal stenosis (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Jülich Supercomputing Centre (JSC)
2. Physik der Medizinischen Bildgebung (INM-4)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. Scientific Computing (FUEK411) (FUEK411)
3. 411 - Computational Science and Mathematical Methods (POF2-411) (POF2-411)
4. 89573 - Neuroimaging (POF2-89573) (POF2-89573)

Appears in the scientific report 2010

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